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Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability

Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palm...

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Main Authors: Straßburger, Katrin (Author) , Kang, Evangeline (Author) , Teleman, Aurelio A. (Author)
Format: Article (Journal)
Language:English
Published: February 8, 2019
In: PLOS ONE
Year: 2019, Volume: 14, Issue: 2
ISSN:1932-6203
DOI:10.1371/journal.pone.0198149
Online Access:Verlag, Volltext: https://doi.org/10.1371/journal.pone.0198149
Verlag, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198149
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Author Notes:Katrin Strassburger, Evangeline Kang, Aurelio A. Teleman

MARC

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520 |a Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8. 
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