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CIC protein instability contributes to tumorigenesis in glioblastoma

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in o...

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Bibliographic Details
Main Authors: Bunda, Severa (Author) , Deimling, Andreas von (Author)
Format: Article (Journal)
Language:English
Published: 08 February 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-018-08087-9
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-018-08087-9
Verlag, Volltext: https://www.nature.com/articles/s41467-018-08087-9
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Author Notes:Severa Bunda, Pardeep Heir, Julie Metcalf, Annie Si Cong Li, Sameer Agnihotri, Stefan Pusch, Mamatjan Yasin, Mira Li, Kelly Burrell, Sheila Mansouri, Olivia Singh, Mark Wilson, Amir Alamsahebpour, Romina Nejad, Bethany Choi, David Kim, Andreas von Deimling, Gelareh Zadeh & Kenneth Aldape

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