Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL
GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been explored. As aberrant GATA3 mRNA expression has been linked to canceroge...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 September 2016
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| In: |
Journal of hematology & oncology
Year: 2016, Jahrgang: 9, Pages: 1-12 |
| ISSN: | 1756-8722 |
| DOI: | 10.1186/s13045-016-0324-8 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1186/s13045-016-0324-8
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| Verfasserangaben: | L. Fransecky, M. Neumann, S. Heesch, C. Schlee, J. Ortiz-Tanchez, S. Heller, M. Mossner, S. Schwartz, L. H. Mochmann, K. Isaakidis, L. Bastian, U. R. Kees, T. Herold, K. Spiekermann, N. Gökbuget and C. D. Baldus |
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| 520 | |a GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been explored. As aberrant GATA3 mRNA expression has been linked to cancerogenesis, we investigated the role of GATA3 in early T cell precursor acute lymphoblastic leukemia (ETP-ALL). | ||
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