Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade
Tumor cells interact with blood constituents and these interactions promote metastasis. Selectins are vascular receptors facilitating interactions of tumor cells with platelets, leukocytes, and endothelium, but the role of endothelial E-selectin remains unclear. Here we show that E-selectin is a maj...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 15, 2016
|
| In: |
Cancer research
Year: 2016, Jahrgang: 76, Heft: 18, Pages: 5302-5312 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-16-0784 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1158/0008-5472.CAN-16-0784 Verlag, Volltext: http://cancerres.aacrjournals.org/content/76/18/5302 
|
| Verfasserangaben: | Irina Häuselmann, Marko Roblek, Darya Protsyuk, Volker Huck, Lucia Knopfova, Sandra Grässle, Alexander T. Bauer, Stefan W. Schneider, and Lubor Borsig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1670664821 | ||
| 003 | DE-627 | ||
| 005 | 20220816203257.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190806s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1158/0008-5472.CAN-16-0784 |2 doi | |
| 035 | |a (DE-627)1670664821 | ||
| 035 | |a (DE-599)KXP1670664821 | ||
| 035 | |a (OCoLC)1341235407 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Häuselmann, Irina |d 1986- |e VerfasserIn |0 (DE-588)107763188X |0 (DE-627)837316340 |0 (DE-576)446564508 |4 aut | |
| 245 | 1 | 0 | |a Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade |c Irina Häuselmann, Marko Roblek, Darya Protsyuk, Volker Huck, Lucia Knopfova, Sandra Grässle, Alexander T. Bauer, Stefan W. Schneider, and Lubor Borsig |
| 264 | 1 | |c September 15, 2016 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.08.2019 | ||
| 520 | |a Tumor cells interact with blood constituents and these interactions promote metastasis. Selectins are vascular receptors facilitating interactions of tumor cells with platelets, leukocytes, and endothelium, but the role of endothelial E-selectin remains unclear. Here we show that E-selectin is a major receptor for monocyte recruitment to tumor cell-activated endothelium. Experimental and spontaneous lung metastasis using murine tumor cells, without E-selectin ligands, were attenuated in E-selectin-deficient mice. Tumor cell-derived CCL2 promoted endothelial activation, resulting in enhanced endothelial E-selectin expression. The recruitment of inflammatory monocytes to metastasizing tumor cells was dependent on the local endothelial activation and the presence of E-selectin. Monocytes promoted transendothelial migration of tumor cells through the induction of E-selectin-dependent endothelial retractions and a subsequent modulation of tight junctions through dephosphorylation of VE-cadherin. Thus, endothelial E-selectin shapes the tumor microenvironment through the recruitment, adhesion, and activation of monocytes that facilitate tumor cell extravasation and thereby metastasis. These findings provide evidence that endothelial E-selectin is a novel factor contributing to endothelial retraction required for efficient lung metastasis. Cancer Res; 76(18); 5302-12. ©2016 AACR. | ||
| 700 | 1 | |a Huck, Volker |d 1978- |e VerfasserIn |0 (DE-588)134286537 |0 (DE-627)692230297 |0 (DE-576)300425651 |4 aut | |
| 700 | 1 | |a Bauer, Alexander |d 1978- |e VerfasserIn |0 (DE-588)143496425 |0 (DE-627)646577778 |0 (DE-576)337385572 |4 aut | |
| 700 | 1 | |a Schneider, Stefan W. |d 1966- |e VerfasserIn |0 (DE-588)137570546 |0 (DE-627)593664868 |0 (DE-576)304124702 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer research |d Philadelphia, Pa. : AACR, 1941 |g 76(2016), 18, Seite 5302-5312 |h Online-Ressource |w (DE-627)325489955 |w (DE-600)2036785-5 |w (DE-576)094502226 |x 1538-7445 |7 nnas |a Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade |
| 773 | 1 | 8 | |g volume:76 |g year:2016 |g number:18 |g pages:5302-5312 |g extent:11 |a Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade |
| 856 | 4 | 0 | |u https://doi.org/10.1158/0008-5472.CAN-16-0784 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://cancerres.aacrjournals.org/content/76/18/5302 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190806 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 137570546 |a Schneider, Stefan W. |m 137570546:Schneider, Stefan W. |d 60000 |d 61900 |e 60000PS137570546 |e 61900PS137570546 |k 0/60000/ |k 1/60000/61900/ |p 8 | ||
| 998 | |g 143496425 |a Bauer, Alexander |m 143496425:Bauer, Alexander |d 60000 |d 61900 |e 60000PB143496425 |e 61900PB143496425 |k 0/60000/ |k 1/60000/61900/ |p 7 | ||
| 998 | |g 134286537 |a Huck, Volker |m 134286537:Huck, Volker |d 60000 |d 61900 |e 60000PH134286537 |e 61900PH134286537 |k 0/60000/ |k 1/60000/61900/ |p 4 | ||
| 999 | |a KXP-PPN1670664821 |e 3504665408 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Irina Häuselmann, Marko Roblek, Darya Protsyuk, Volker Huck, Lucia Knopfova, Sandra Grässle, Alexander T. Bauer, Stefan W. Schneider, and Lubor Borsig"]},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"September 15, 2016"}],"id":{"doi":["10.1158/0008-5472.CAN-16-0784"],"eki":["1670664821"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"pubHistory":["Volume 1, issue 1 (1 January 1941)-"],"part":{"issue":"18","pages":"5302-5312","year":"2016","extent":"11","volume":"76","text":"76(2016), 18, Seite 5302-5312"},"note":["Gesehen am 31.03.25","Fortsetzung der Druck-Ausgabe"],"disp":"Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascadeCancer research","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"325489955","corporate":[{"role":"isb","display":"American Association for Cancer Research","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"title":[{"title_sort":"Cancer research","title":"Cancer research"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Philadelphia, Pa.","publisher":"AACR","dateIssuedKey":"1941","dateIssuedDisp":"1941-"}],"id":{"issn":["1538-7445"],"eki":["325489955"],"zdb":["2036785-5"]},"name":{"displayForm":["American Association for Cancer Research"]}}],"person":[{"roleDisplay":"VerfasserIn","display":"Häuselmann, Irina","role":"aut","family":"Häuselmann","given":"Irina"},{"roleDisplay":"VerfasserIn","display":"Huck, Volker","role":"aut","family":"Huck","given":"Volker"},{"family":"Bauer","given":"Alexander","display":"Bauer, Alexander","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Stefan W.","family":"Schneider","role":"aut","roleDisplay":"VerfasserIn","display":"Schneider, Stefan W."}],"title":[{"title":"Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade","title_sort":"Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade"}],"note":["Gesehen am 06.08.2019"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1670664821"} | ||
| SRT | |a HAEUSELMANMONOCYTEIN1520 | ||