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Management of CML-blast crisis

Tyrosine kinase inhibitors (TKI) have moderately improved survival in BC, but a median survival of less than 1 year is still unsatisfactory. This article reviews the various tests required for diagnosis of BC, features at diagnosis, treatment modalities (intensive chemotherapy, TKI, allo-SCT and a s...

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Main Authors: Hehlmann, Rüdiger (Author) , Saußele, Susanne (Author) , Voskanyan, Astghik (Author)
Format: Article (Journal)
Language:English
Published: September 2016
In: Best practice & research
Year: 2016, Volume: 29, Issue: 3, Pages: 295-307
ISSN:1532-1924
DOI:10.1016/j.beha.2016.10.005
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.beha.2016.10.005
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1521692616300585
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Author Notes:Rüdiger Hehlmann, Susanne Saußele, Astghik Voskanyan, Richard T. Silver

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520 |a Tyrosine kinase inhibitors (TKI) have moderately improved survival in BC, but a median survival of less than 1 year is still unsatisfactory. This article reviews the various tests required for diagnosis of BC, features at diagnosis, treatment modalities (intensive chemotherapy, TKI, allo-SCT and a selection of investigational agents), options of prevention and predictors of progression. The best prognosis is observed in patients that achieve a 2nd CP. Allo-SCT probably further improves prognosis of patients in 2nd CP. The choice of TKI should be directed by the mutation profile of the patient. BC can be prevented. A careful analysis of risk factors for progression may help. Current treatment options are combined in a concluding strategy for the management of BC. 
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