Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation
During biogenesis of the eukaryotic 60S ribosome, a large rotational movement of the 5S RNP is required to achieve its mature position. By analyzing extragenic suppressors of crg1—a key factor required for rotation—the authors provide mechanistic insight into a key step of ribosome biogenesis.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 October 2018
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| In: |
Nature Communications
Year: 2018, Volume: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-06660-w |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41467-018-06660-w Verlag, Volltext: https://www.nature.com/articles/s41467-018-06660-w 
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| Author Notes: | Matthias Thoms, Valentin Mitterer, Lukas Kater, Laurent Falquet, Roland Beckmann, Dieter Kressler, & Ed Hurt |
| Summary: | During biogenesis of the eukaryotic 60S ribosome, a large rotational movement of the 5S RNP is required to achieve its mature position. By analyzing extragenic suppressors of crg1—a key factor required for rotation—the authors provide mechanistic insight into a key step of ribosome biogenesis. |
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| Item Description: | Gesehen am 07.08.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-06660-w |