Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy
Perioperative systemic treatment is standard of care for Caucasian patients with locally advanced, resectable gastric adenocarcinoma. The prognostic relevance of the microsatellite instability (MSI) status in patients undergoing neoadjuvant chemotherapy followed by resection is unclear. We analyzed...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
International journal of cancer
Year: 2019, Jahrgang: 144, Heft: 7, Pages: 1697-1703 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.32030 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/ijc.32030 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32030 
|
| Verfasserangaben: | Georg Martin Haag, Elena Czink, Aysel Ahadova, Thomas Schmidt, Leila Sisic, Susanne Blank, Ulrike Heger, Leonidas Apostolidis, Anne Katrin Berger, Christoph Springfeld, Felix Lasitschka, Dirk Jäger, Magnus von Knebel Doeberitz and Matthias Kloor |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 167073031X | ||
| 003 | DE-627 | ||
| 005 | 20241113162945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190807s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.32030 |2 doi | |
| 035 | |a (DE-627)167073031X | ||
| 035 | |a (DE-599)KXP167073031X | ||
| 035 | |a (OCoLC)1341235525 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Haag, Georg Martin |d 1979- |e VerfasserIn |0 (DE-588)133390934 |0 (DE-627)544043863 |0 (DE-576)29981548X |4 aut | |
| 245 | 1 | 0 | |a Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy |c Georg Martin Haag, Elena Czink, Aysel Ahadova, Thomas Schmidt, Leila Sisic, Susanne Blank, Ulrike Heger, Leonidas Apostolidis, Anne Katrin Berger, Christoph Springfeld, Felix Lasitschka, Dirk Jäger, Magnus von Knebel Doeberitz and Matthias Kloor |
| 264 | 1 | |c 2019 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online 29 Nov 2018 | ||
| 500 | |a Gesehen am 07.08.2019 | ||
| 520 | |a Perioperative systemic treatment is standard of care for Caucasian patients with locally advanced, resectable gastric adenocarcinoma. The prognostic relevance of the microsatellite instability (MSI) status in patients undergoing neoadjuvant chemotherapy followed by resection is unclear. We analyzed the association of the MSI status with histological regression and clinical outcome in patients undergoing neoadjuvant systemic treatment. Tumor tissue from patients undergoing neoadjuvant chemotherapy followed by resection for gastric or gastroesophageal-junction adenocarcinoma was analyzed for MSI status using a mononucleotide marker panel encompassing the markers BAT25, BAT26, and CAT25. Histological regression, relapse-free survival and overall survival were calculated and correlated with MSI status. We identified the MSI-H phenotype in 9 (8.9%) out of 101 analyzed tumors. Though a poor histological response was observed in eight out of nine MSI-H patients, overall survival was significantly better for patients with MSI-H compared to MSS tumors (median overall survival not reached vs. 38.6 months, log-rank test p = 0.014). Among MSI-H patients, an unexpected long-term survival after relapse was observed. Our data indicate that the MSI-H phenotype is a favorable prognostic marker in gastric cancer patients undergoing neoadjuvant treatment. The benefit of perioperative cytotoxic treatment in patients with MSI-H gastric cancer, however, remains questionable. Future trials should stratify patients according to their MSI status, and novel treatment modalities focusing on MSI-H tumors should be considered. | ||
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a gastric cancer | |
| 650 | 4 | |a GE-junction cancer | |
| 650 | 4 | |a microsatellite instability | |
| 650 | 4 | |a MSI | |
| 650 | 4 | |a neoadjuvant | |
| 700 | 1 | |a Busch, Elena |d 1987- |e VerfasserIn |0 (DE-588)1073257738 |0 (DE-627)828739145 |0 (DE-576)434772917 |4 aut | |
| 700 | 1 | |a Ahadova, Aysel |d 1988- |e VerfasserIn |0 (DE-588)106835268X |0 (DE-627)820167118 |0 (DE-576)427724783 |4 aut | |
| 700 | 1 | |a Schmidt, Thomas |d 1980- |e VerfasserIn |0 (DE-588)132383152 |0 (DE-627)521950023 |0 (DE-576)260799149 |4 aut | |
| 700 | 1 | |a Peters, Leila |d 1982- |e VerfasserIn |0 (DE-588)1031408770 |0 (DE-627)736378405 |0 (DE-576)378855654 |4 aut | |
| 700 | 1 | |a Blank, Susanne |d 1984- |e VerfasserIn |0 (DE-588)1014414253 |0 (DE-627)705225097 |0 (DE-576)34875714X |4 aut | |
| 700 | 1 | |a Heger, Ulrike |d 1979- |e VerfasserIn |0 (DE-588)13610536X |0 (DE-627)694083054 |0 (DE-576)300834519 |4 aut | |
| 700 | 1 | |a Apostolidis, Leonidas |d 1981- |e VerfasserIn |0 (DE-588)139136932 |0 (DE-627)703220594 |0 (DE-576)309798590 |4 aut | |
| 700 | 1 | |a Berger, Anne Katrin |d 1978- |e VerfasserIn |0 (DE-588)132177889 |0 (DE-627)519022424 |0 (DE-576)298988380 |4 aut | |
| 700 | 1 | |a Springfeld, Christoph |d 1972- |e VerfasserIn |0 (DE-588)123388910 |0 (DE-627)706281039 |0 (DE-576)293689385 |4 aut | |
| 700 | 1 | |a Lasitschka, Felix |d 1979- |e VerfasserIn |0 (DE-588)140496343 |0 (DE-627)618903542 |0 (DE-576)318526077 |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 700 | 1 | |a Kloor, Matthias |d 1972- |e VerfasserIn |0 (DE-588)124552803 |0 (DE-627)363416609 |0 (DE-576)294228616 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 144(2019), 7, Seite 1697-1703 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy |
| 773 | 1 | 8 | |g volume:144 |g year:2019 |g number:7 |g pages:1697-1703 |g extent:8 |a Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.32030 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32030 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190807 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124552803 |a Kloor, Matthias |m 124552803:Kloor, Matthias |d 910000 |d 912000 |e 910000PK124552803 |e 912000PK124552803 |k 0/910000/ |k 1/910000/912000/ |p 14 |y j | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |e 910000PK1022165291 |e 912000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |p 13 | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 12 | ||
| 998 | |g 140496343 |a Lasitschka, Felix |m 140496343:Lasitschka, Felix |d 910000 |d 912000 |e 910000PL140496343 |e 912000PL140496343 |k 0/910000/ |k 1/910000/912000/ |p 11 | ||
| 998 | |g 123388910 |a Springfeld, Christoph |m 123388910:Springfeld, Christoph |d 910000 |d 910100 |e 910000PS123388910 |e 910100PS123388910 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 132177889 |a Berger, Anne Katrin |m 132177889:Berger, Anne Katrin |d 910000 |e 910000PB132177889 |k 0/910000/ |p 9 | ||
| 998 | |g 139136932 |a Apostolidis, Leonidas |m 139136932:Apostolidis, Leonidas |d 910000 |d 910100 |e 910000PA139136932 |e 910100PA139136932 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 13610536X |a Heger, Ulrike |m 13610536X:Heger, Ulrike |d 910000 |d 910200 |e 910000PH13610536X |e 910200PH13610536X |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 1014414253 |a Blank, Susanne |m 1014414253:Blank, Susanne |d 910000 |d 910200 |e 910000PB1014414253 |e 910200PB1014414253 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 1031408770 |a Peters, Leila |m 1031408770:Peters, Leila |d 910000 |d 910200 |e 910000PP1031408770 |e 910200PP1031408770 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 132383152 |a Schmidt, Thomas |m 132383152:Schmidt, Thomas |d 910000 |d 910200 |d 50000 |e 910000PS132383152 |e 910200PS132383152 |e 50000PS132383152 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 4 | ||
| 998 | |g 106835268X |a Ahadova, Aysel |m 106835268X:Ahadova, Aysel |d 910000 |d 912000 |e 910000PA106835268X |e 912000PA106835268X |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 1073257738 |a Busch, Elena |m 1073257738:Busch, Elena |d 910000 |d 910100 |e 910000PB1073257738 |e 910100PB1073257738 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 133390934 |a Haag, Georg Martin |m 133390934:Haag, Georg Martin |d 910000 |d 910100 |e 910000PH133390934 |e 910100PH133390934 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN167073031X |e 3504960426 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"relHost":[{"note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"title":[{"subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer","title":"International journal of cancer","title_sort":"International journal of cancer"}],"origin":[{"publisher":"Wiley-Liss","publisherPlace":"Bognor Regis","dateIssuedKey":"1966","dateIssuedDisp":"1966-"}],"titleTranslated":[{"translated":"Journal international du cancer"}],"disp":"Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapyInternational journal of cancer","physDesc":[{"extent":"Online-Ressource"}],"recId":"269532781","part":{"year":"2019","volume":"144","pages":"1697-1703","issue":"7","extent":"8","text":"144(2019), 7, Seite 1697-1703"},"id":{"issn":["1097-0215"],"eki":["269532781"],"doi":["10.1002/(ISSN)1097-0215"],"zdb":["1474822-8"]},"corporate":[{"display":"International Union against Cancer","role":"isb"}],"pubHistory":["1.1966 -"],"titleAlt":[{"title":"Predictive oncology"}]}],"person":[{"role":"aut","given":"Georg Martin","family":"Haag","display":"Haag, Georg Martin"},{"given":"Elena","role":"aut","family":"Busch","display":"Busch, Elena"},{"display":"Ahadova, Aysel","given":"Aysel","role":"aut","family":"Ahadova"},{"display":"Schmidt, Thomas","family":"Schmidt","role":"aut","given":"Thomas"},{"family":"Peters","given":"Leila","role":"aut","display":"Peters, Leila"},{"family":"Blank","given":"Susanne","role":"aut","display":"Blank, Susanne"},{"display":"Heger, Ulrike","role":"aut","given":"Ulrike","family":"Heger"},{"family":"Apostolidis","role":"aut","given":"Leonidas","display":"Apostolidis, Leonidas"},{"family":"Berger","role":"aut","given":"Anne Katrin","display":"Berger, Anne Katrin"},{"family":"Springfeld","given":"Christoph","role":"aut","display":"Springfeld, Christoph"},{"family":"Lasitschka","given":"Felix","role":"aut","display":"Lasitschka, Felix"},{"display":"Jäger, Dirk","family":"Jäger","given":"Dirk","role":"aut"},{"family":"Knebel Doeberitz","given":"Magnus von","role":"aut","display":"Knebel Doeberitz, Magnus von"},{"family":"Kloor","given":"Matthias","role":"aut","display":"Kloor, Matthias"}],"title":[{"title_sort":"Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy","title":"Prognostic significance of microsatellite-instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Online 29 Nov 2018","Gesehen am 07.08.2019"],"recId":"167073031X","physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Georg Martin Haag, Elena Czink, Aysel Ahadova, Thomas Schmidt, Leila Sisic, Susanne Blank, Ulrike Heger, Leonidas Apostolidis, Anne Katrin Berger, Christoph Springfeld, Felix Lasitschka, Dirk Jäger, Magnus von Knebel Doeberitz and Matthias Kloor"]},"id":{"doi":["10.1002/ijc.32030"],"eki":["167073031X"]}} | ||
| SRT | |a HAAGGEORGMPROGNOSTIC2019 | ||