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Spatiotemporal evolution of venous narrowing in acute MS lesions

Objective To investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs). - Methods We retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system in...

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Bibliographic Details
Main Authors: Eisele, Philipp (Author) , Szabo, Kristina (Author) , Ebert, Anne (Author) , Platten, Michael (Author) , Gass, Achim (Author)
Format: Article (Journal)
Language:English
Published: January 18, 2018
In: Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
Year: 2018, Volume: 5, Issue: 2, Pages: 1-8
ISSN:2332-7812
DOI:10.1212/NXI.0000000000000440
Online Access:Verlag, Volltext: https://doi.org/10.1212/NXI.0000000000000440
Verlag, Volltext: http://nn.neurology.org/lookup/doi/10.1212/NXI.0000000000000440
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Author Notes:Philipp Eisele, Kristina Szabo, Anne Ebert, Wolfgang Brueck, Michael Platten, and Achim Gass
Description
Summary:Objective To investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs). - Methods We retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast enhancement. The mean diameter of veins at the time point of contrast enhancement was compared with the mean diameter of veins before and after contrast enhancement. - Results A total of 40 acute contrast-enhancing lesions with a corresponding intralesional central vein were included in the study. The mean diameter of intralesional veins at the time of contrast enhancement (0.80 ± 0.12 mm) was smaller than that at before (1.16 ± 0.19 mm) and after contrast enhancement (1.07 ± 0.15 mm; p < 0.001 for all comparisons). - Conclusions Our findings contribute to the increasing database of plaque development and evolution. The smaller diameter of intralesional veins on SWI at the time of blood-brain barrier breakdown may reflect morphologic changes because of perivascular inflammation and/or decreased levels of deoxygenated hemoglobin.
Item Description:Gesehen am 08.08.2019
Physical Description:Online Resource
ISSN:2332-7812
DOI:10.1212/NXI.0000000000000440

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