Pathogenese der Psoriasis vulgaris
Psoriasis is an inflammatory T cell-mediated autoimmune disease of skin and joints that affects 2-4 % of the adult population and 0.1-1 % of children. Genetic susceptibility, environmental triggering factors, and innate immune processes initiate psoriasis pathogenesis that results in an adaptive aut...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
31. Mai 2016
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| In: |
Der Hautarzt
Year: 2016, Jahrgang: 67, Heft: 6, Pages: 422-431 |
| ISSN: | 1432-1173 |
| DOI: | 10.1007/s00105-016-3800-8 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00105-016-3800-8
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| Verfasserangaben: | K. Schäkel, M.P. Schön, K. Ghoreschi |
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| 520 | |a Psoriasis is an inflammatory T cell-mediated autoimmune disease of skin and joints that affects 2-4 % of the adult population and 0.1-1 % of children. Genetic susceptibility, environmental triggering factors, and innate immune processes initiate psoriasis pathogenesis that results in an adaptive autoreactive response. The T cell response is orchestrated by CD 8+ T cells in the epidermis and by CD 4+ T cells in the dermis that predominantly produce interleukin-17 (IL‑17). Research of the past 15 years unraveled cellular and molecular mechanisms as well as cytokines like TNF-α or IL‑23 that contribute to psoriatic inflammation. This knowledge has been translated into clinical practice and a number of antipsoriatic small molecules and immunobiologics are now available. Here, we discuss the current principles of psoriasis pathogenesis in the context of modern therapies. | ||
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