Genome-wide association study of pathological gambling
Background - Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes and pathways may improve understanding of aetiology and facilitate therapy and prevention. Here, we report the first genome-wide associat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 June 2016
|
| In: |
European psychiatry
Year: 2016, Volume: 36, Pages: 38-46 |
| ISSN: | 1778-3585 |
| DOI: | 10.1016/j.eurpsy.2016.04.001 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.eurpsy.2016.04.001 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0924933816300050 
|
| Author Notes: | M. Lang, T. Leménager, F. Streit, M. Fauth-Bühler, J. Frank, D. Juraeva, S.H. Witt, F. Degenhardt, A. Hofmann, S. Heilmann-Heimbach, F. Kiefer, B. Brors, H.-J. Grabe, U. John, A. Bischof, G. Bischof, U. Völker, G. Homuth, M. Beutel, P.A. Lind, S.E. Medland, W.S. Slutske, N.G. Martin, H. Völzke, M.M. Nöthen, C. Meyer, H.-J. Rumpf, F.M. Wurst, M. Rietschel, K.F. Mann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1671058607 | ||
| 003 | DE-627 | ||
| 005 | 20230428190736.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190809s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eurpsy.2016.04.001 |2 doi | |
| 035 | |a (DE-627)1671058607 | ||
| 035 | |a (DE-599)KXP1671058607 | ||
| 035 | |a (OCoLC)1341235461 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lang, Maren |d 1978- |e VerfasserIn |0 (DE-588)1037316150 |0 (DE-627)755438345 |0 (DE-576)391313207 |4 aut | |
| 245 | 1 | 0 | |a Genome-wide association study of pathological gambling |c M. Lang, T. Leménager, F. Streit, M. Fauth-Bühler, J. Frank, D. Juraeva, S.H. Witt, F. Degenhardt, A. Hofmann, S. Heilmann-Heimbach, F. Kiefer, B. Brors, H.-J. Grabe, U. John, A. Bischof, G. Bischof, U. Völker, G. Homuth, M. Beutel, P.A. Lind, S.E. Medland, W.S. Slutske, N.G. Martin, H. Völzke, M.M. Nöthen, C. Meyer, H.-J. Rumpf, F.M. Wurst, M. Rietschel, K.F. Mann |
| 264 | 1 | |c 14 June 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.08.2019 | ||
| 520 | |a Background - Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes and pathways may improve understanding of aetiology and facilitate therapy and prevention. Here, we report the first genome-wide association study of pathological gambling. Our aims were to identify pathways involved in pathological gambling, and examine whether there is a genetic overlap between pathological gambling and alcohol dependence. - Methods - Four hundred and forty-five individuals with a diagnosis of pathological gambling according to the Diagnostic and Statistical Manual of Mental Disorders were recruited in Germany, and 986 controls were drawn from a German general population sample. A genome-wide association study of pathological gambling comprising single marker, gene-based, and pathway analyses, was performed. Polygenic risk scores were generated using data from a German genome-wide association study of alcohol dependence. - Results - No genome-wide significant association with pathological gambling was found for single markers or genes. Pathways for Huntington's disease (P-value=6.63x10-3); 5′-adenosine monophosphate-activated protein kinase signalling (P-value=9.57x10-3); and apoptosis (P-value=1.75x10-2) were significant. Polygenic risk score analysis of the alcohol dependence dataset yielded a one-sided nominal significant P-value in subjects with pathological gambling, irrespective of comorbid alcohol dependence status. - Conclusions - The present results accord with previous quantitative formal genetic studies which showed genetic overlap between non-substance- and substance-related addictions. Furthermore, pathway analysis suggests shared pathology between Huntington's disease and pathological gambling. This finding is consistent with previous imaging studies. | ||
| 650 | 4 | |a Addiction | |
| 650 | 4 | |a Association | |
| 650 | 4 | |a Gambling | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Genome-wide | |
| 700 | 1 | |a Witt, Stephanie |d 1970- |e VerfasserIn |0 (DE-588)132177897 |0 (DE-627)519022432 |0 (DE-576)298988399 |4 aut | |
| 700 | 1 | |a Kiefer, Falk |d 1969- |e VerfasserIn |0 (DE-588)140919635 |0 (DE-627)703829033 |0 (DE-576)176310339 |4 aut | |
| 700 | 1 | |a Rietschel, Marcella |d 1957- |e VerfasserIn |0 (DE-588)112785751 |0 (DE-627)505574020 |0 (DE-576)289742307 |4 aut | |
| 700 | 1 | |a Mann, Karl |d 1948- |e VerfasserIn |0 (DE-588)120426455 |0 (DE-627)080667872 |0 (DE-576)187088012 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European psychiatry |d Cambridge : Cambridge University Press, 1991 |g 36(2016), Seite 38-46 |h Online-Ressource |w (DE-627)320445070 |w (DE-600)2005377-0 |w (DE-576)10684606X |x 1778-3585 |7 nnas |a Genome-wide association study of pathological gambling |
| 773 | 1 | 8 | |g volume:36 |g year:2016 |g pages:38-46 |g extent:9 |a Genome-wide association study of pathological gambling |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.eurpsy.2016.04.001 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0924933816300050 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190809 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 120426455 |a Mann, Karl |m 120426455:Mann, Karl |d 60000 |e 60000PM120426455 |k 0/60000/ |p 30 |y j | ||
| 998 | |g 112785751 |a Rietschel, Marcella |m 112785751:Rietschel, Marcella |d 60000 |e 60000PR112785751 |k 0/60000/ |p 29 | ||
| 998 | |g 140919635 |a Kiefer, Falk |m 140919635:Kiefer, Falk |d 60000 |e 60000PK140919635 |k 0/60000/ |p 11 | ||
| 998 | |g 132177897 |a Witt, Stephanie |m 132177897:Witt, Stephanie |d 60000 |e 60000PW132177897 |k 0/60000/ |p 7 | ||
| 999 | |a KXP-PPN1671058607 |e 3506181149 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"14 June 2016"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Genome-wide association study of pathological gambling","title_sort":"Genome-wide association study of pathological gambling"}],"person":[{"role":"aut","family":"Lang","given":"Maren","display":"Lang, Maren"},{"display":"Witt, Stephanie","family":"Witt","given":"Stephanie","role":"aut"},{"role":"aut","display":"Kiefer, Falk","given":"Falk","family":"Kiefer"},{"display":"Rietschel, Marcella","family":"Rietschel","given":"Marcella","role":"aut"},{"role":"aut","family":"Mann","given":"Karl","display":"Mann, Karl"}],"note":["Gesehen am 09.08.2019"],"name":{"displayForm":["M. Lang, T. Leménager, F. Streit, M. Fauth-Bühler, J. Frank, D. Juraeva, S.H. Witt, F. Degenhardt, A. Hofmann, S. Heilmann-Heimbach, F. Kiefer, B. Brors, H.-J. Grabe, U. John, A. Bischof, G. Bischof, U. Völker, G. Homuth, M. Beutel, P.A. Lind, S.E. Medland, W.S. Slutske, N.G. Martin, H. Völzke, M.M. Nöthen, C. Meyer, H.-J. Rumpf, F.M. Wurst, M. Rietschel, K.F. Mann"]},"relHost":[{"part":{"pages":"38-46","volume":"36","extent":"9","year":"2016","text":"36(2016), Seite 38-46"},"disp":"Genome-wide association study of pathological gamblingEuropean psychiatry","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"320445070","id":{"eki":["320445070"],"issn":["1778-3585"],"zdb":["2005377-0"]},"note":["Gesehen am 20.05.2020","Fortsetzung der Druck-Ausgabe"],"pubHistory":["Nachgewiesen 6.1991 -"],"title":[{"title_sort":"European psychiatry","subtitle":"the official journal of the Association of European Psychiatrists (AEP)","title":"European psychiatry"}],"origin":[{"dateIssuedDisp":"1991-","publisherPlace":"Cambridge ; Amsterdam","publisher":"Cambridge University Press ; Elsevier Science","dateIssuedKey":"1991"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"id":{"doi":["10.1016/j.eurpsy.2016.04.001"],"eki":["1671058607"]},"recId":"1671058607","language":["eng"],"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a LANGMARENWGENOMEWIDE1420 | ||