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Clinical significance of signs of autoimmune colitis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography of 100 stage-IV melanoma patients

Aim: Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. Patients & methods: We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of 18F-fluorodeoxyglucose positron emission tomogr...

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Main Authors: Lang, Nina (Author) , Dick, Julika (Author) , Slynko, Alla (Author) , Schulz, Carsten (Author) , Dimitrakopoulou-Strauss, Antonia (Author) , Sachpekidis, Christos (Author) , Enk, Alexander (Author) , Hassel, Jessica C. (Author)
Format: Article (Journal)
Language:English
Published: 15 May 2019
In: Immunotherapy
Year: 2019, Volume: 11, Issue: 8, Pages: 667-676
ISSN:1750-7448
DOI:10.2217/imt-2018-0146
Online Access:Verlag, Volltext: http://dx.doi.org/10.2217/imt-2018-0146
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Author Notes:Nina Lang, Julika Dick, Alla Slynko, Carsten Schulz, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis, Alexander H. Enk & Jessica C. Hassel
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Summary:Aim: Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. Patients & methods: We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT). PET evidence of pancolitis ('PET-colitis') was correlated with clinical variables. Results: We observed a significant correlation between PET-colitis and clinically significant diarrhoea, although PET-colitis was more frequent (49 vs 29% of patients, respectively). Neither PET-colitis nor diarrhoea was significantly correlated with response to therapy. Other immune-related adverse events, however, such as hypophysitis and hepatitis were associated with response to therapy and overall survival. Conclusion: Increased 18F-FDG uptake in the colon correlated with clinical symptoms but did not predict clinical outcome to ipilimumab.
Item Description:Gesehen am 13.08.2019
Im Titel ist die Zahl "18" hochgestellt
Physical Description:Online Resource
ISSN:1750-7448
DOI:10.2217/imt-2018-0146

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