Clinical significance of signs of autoimmune colitis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography of 100 stage-IV melanoma patients
Aim: Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. Patients & methods: We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of 18F-fluorodeoxyglucose positron emission tomogr...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 May 2019
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| In: |
Immunotherapy
Year: 2019, Volume: 11, Issue: 8, Pages: 667-676 |
| ISSN: | 1750-7448 |
| DOI: | 10.2217/imt-2018-0146 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.2217/imt-2018-0146
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| Author Notes: | Nina Lang, Julika Dick, Alla Slynko, Carsten Schulz, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis, Alexander H. Enk & Jessica C. Hassel |
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| 245 | 1 | 0 | |a Clinical significance of signs of autoimmune colitis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography of 100 stage-IV melanoma patients |c Nina Lang, Julika Dick, Alla Slynko, Carsten Schulz, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis, Alexander H. Enk & Jessica C. Hassel |
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| 520 | |a Aim: Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. Patients & methods: We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT). PET evidence of pancolitis ('PET-colitis') was correlated with clinical variables. Results: We observed a significant correlation between PET-colitis and clinically significant diarrhoea, although PET-colitis was more frequent (49 vs 29% of patients, respectively). Neither PET-colitis nor diarrhoea was significantly correlated with response to therapy. Other immune-related adverse events, however, such as hypophysitis and hepatitis were associated with response to therapy and overall survival. Conclusion: Increased 18F-FDG uptake in the colon correlated with clinical symptoms but did not predict clinical outcome to ipilimumab. | ||
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| 650 | 4 | |a ipilimumab | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a treatment response | |
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