CaRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens
Motivation: Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing. Results: The CRISPR-AnalyzeR for pooled...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Bioinformatics
Year: 2016, Volume: 32, Issue: 4, Pages: 632-634 |
| ISSN: | 1367-4811 |
| DOI: | 10.1093/bioinformatics/btv617 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1093/bioinformatics/btv617 Verlag, Volltext: https://academic.oup.com/bioinformatics/article/32/4/632/1744042 
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| Author Notes: | Jan Winter, Marco Breinig, Florian Heigwer, Dirk Brügemann, Svenja Leible, Oliver Pelz, Tianzuo Zhan and Michael Boutros |
| Summary: | Motivation: Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing. Results: The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports. Availability and implementation: caRpools, manuals and an open virtual appliance are available at http://github.com/boutroslab/caRpools . |
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| Item Description: | Gesehen am 19.08.2019 Advance Access Publication Date: 27 October 2015 |
| Physical Description: | Online Resource |
| ISSN: | 1367-4811 |
| DOI: | 10.1093/bioinformatics/btv617 |