Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway
The wax apple (Syzygium samarangense) is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from S. samarangense leaves: myricitrin and 3,5-di-O-methyl gossypeti...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 May 2019
|
| In: |
Molecules
Year: 2019, Jahrgang: 24, Heft: 9 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24091839 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3390/molecules24091839 Verlag, Volltext: https://www.mdpi.com/1420-3049/24/9/1839 
|
| Verfasserangaben: | Mansour Sobeh, Ganna Petruk, Samir Osman, Mohamed A. El Raey, Paola Imbimbo, Daria Maria Monti and Michael Wink |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1671669851 | ||
| 003 | DE-627 | ||
| 005 | 20210816193359.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190820s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/molecules24091839 |2 doi | |
| 035 | |a (DE-627)1671669851 | ||
| 035 | |a (DE-599)KXP1671669851 | ||
| 035 | |a (OCoLC)1264092490 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Sobeh, Mansour |e VerfasserIn |0 (DE-588)1099730058 |0 (DE-627)859130444 |0 (DE-576)469346434 |4 aut | |
| 245 | 1 | 0 | |a Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway |c Mansour Sobeh, Ganna Petruk, Samir Osman, Mohamed A. El Raey, Paola Imbimbo, Daria Maria Monti and Michael Wink |
| 264 | 1 | |c 13 May 2019 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.08.2019 | ||
| 520 | |a The wax apple (Syzygium samarangense) is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from S. samarangense leaves: myricitrin and 3,5-di-O-methyl gossypetin. Then, we investigated the mechanisms of action of the two compounds against oxidative stress (induced by sodium arsenite) and inflammation (induced by UV light) on human keratinocytes. We could clearly demonstrate that the pre-treatment of cells with both compounds was able to mitigate the negative effects induced by oxidative stress, as no alteration in reactive oxygen species (ROS) production, glutathione (GSH) level, or protein oxidation was observed. Additionally, both compounds were able to modulate mitogen-activated protein kinase (MAPK) signaling pathways to counteract oxidative stress activation. Finally, we showed that 3,5-di-O-methyl gossypetin exerted its antioxidant activity through the nuclear transcription factor-2 (Nrf-2) pathway, stimulating the expression of antioxidant proteins, such as HO-1 and Mn-SOD-3. | ||
| 650 | 4 | |a Syzygium samarangense | |
| 650 | 4 | |a 3,5-di-O-methyl gossypetin | |
| 650 | 4 | |a antioxidants | |
| 650 | 4 | |a eukaryotic cells | |
| 650 | 4 | |a myricitrin | |
| 650 | 4 | |a sodium arsenite | |
| 700 | 1 | |a Wink, Michael |d 1951- |e VerfasserIn |0 (DE-588)124618146 |0 (DE-627)363448519 |0 (DE-576)164659390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecules |d Basel : MDPI, 1996 |g 24(2019,9) Artikel-Nummer 1839, 14 Seiten |h Online-Ressource |w (DE-627)311313132 |w (DE-600)2008644-1 |w (DE-576)281192456 |x 1420-3049 |7 nnas |a Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway |
| 773 | 1 | 8 | |g volume:24 |g year:2019 |g number:9 |g extent:14 |a Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway |
| 856 | 4 | 0 | |u https://doi.org/10.3390/molecules24091839 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1420-3049/24/9/1839 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190820 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124618146 |a Wink, Michael |m 124618146:Wink, Michael |d 160000 |d 160100 |e 160000PW124618146 |e 160100PW124618146 |k 0/160000/ |k 1/160000/160100/ |p 7 |y j | ||
| 998 | |g 1099730058 |a Sobeh, Mansour |m 1099730058:Sobeh, Mansour |d 160000 |d 160100 |e 160000PS1099730058 |e 160100PS1099730058 |k 0/160000/ |k 1/160000/160100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1671669851 |e 3507737329 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Mansour","family":"Sobeh","display":"Sobeh, Mansour","role":"aut"},{"family":"Wink","display":"Wink, Michael","role":"aut","given":"Michael"}],"id":{"doi":["10.3390/molecules24091839"],"eki":["1671669851"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"13 May 2019"}],"title":[{"title_sort":"Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway","title":"Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathway"}],"name":{"displayForm":["Mansour Sobeh, Ganna Petruk, Samir Osman, Mohamed A. El Raey, Paola Imbimbo, Daria Maria Monti and Michael Wink"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1671669851","physDesc":[{"extent":"14 S."}],"relHost":[{"pubHistory":["1.1996 -"],"language":["eng"],"title":[{"subtitle":"a journal of synthetic chemistry and natural product chemistry","title_sort":"Molecules","title":"Molecules"}],"disp":"Isolation of myricitrin and 3,5-di-O-methyl gossypetin from Syzygium samarangense and evaluation of their involvement in protecting keratinocytes against oxidative stress via activation of the Nrf-2 pathwayMolecules","name":{"displayForm":["Molecular Diversity Preservation International"]},"origin":[{"publisher":"MDPI","dateIssuedKey":"1996","publisherPlace":"Basel","dateIssuedDisp":"1996-"}],"id":{"zdb":["2008644-1"],"eki":["311313132"],"issn":["1420-3049"]},"part":{"volume":"24","extent":"14","text":"24(2019,9) Artikel-Nummer 1839, 14 Seiten","issue":"9","year":"2019"},"note":["Gesehen am 25.06.20"],"recId":"311313132","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"language":["eng"],"note":["Gesehen am 20.08.2019"]} | ||
| SRT | |a SOBEHMANSOISOLATIONO1320 | ||