Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for the effect...

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Main Authors: Petersen, Bodil (Author) , Busch, Cornelius (Author) , Schaack, Dominik (Author) , Lasitschka, Felix (Author)
Format: Article (Journal)
Language:English
Published: 03 June 2019
In: Respiratory research
Year: 2019, Volume: 20
ISSN:1465-993X
DOI:10.1186/s12931-019-1062-6
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12931-019-1062-6
Verlag, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1062-6
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Author Notes:Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch and Fumito Ichinose
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Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia by Petersen, Bodil (Author) , Busch, Cornelius (Author) , Schaack, Dominik (Author) , Lasitschka, Felix (Author) ,

BioMed Central 06 Aug. 2019 Universitätsbibliothek Heidelberg 06 Aug. 2019

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