Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans
Introduction - Knowledge about the pharmacological properties of traditional TCM formulas is scarce as is their impact on aging. This study evaluated the potential effects of Sijunzi Tang Decoction (SJZTD), Si-Wu-Tang Decoction (SWTD), and Liuwei Dihuang Decoction (LWDHD) against oxidative stress an...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 2016
|
| In: |
European journal of integrative medicine
Year: 2016, Jahrgang: 8, Heft: 4, Pages: 526-532 |
| ISSN: | 1876-3839 |
| DOI: | 10.1016/j.eujim.2016.03.009 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.eujim.2016.03.009 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1876382016300257 
|
| Verfasserangaben: | Andrea Schlotterer, Henry Johannes Greten, Bjoern Andrew Remppis, Georgi Kukudov, Thomas Efferth, Jorge Machado, Per Humpert, Hans-Peter Hammes, Michael Morcos |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1671931823 | ||
| 003 | DE-627 | ||
| 005 | 20230426135351.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190823s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eujim.2016.03.009 |2 doi | |
| 035 | |a (DE-627)1671931823 | ||
| 035 | |a (DE-599)KXP1671931823 | ||
| 035 | |a (OCoLC)1341238444 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schlotterer, Andrea |d 1971- |e VerfasserIn |0 (DE-588)1072656302 |0 (DE-627)827960549 |0 (DE-576)434161705 |4 aut | |
| 245 | 1 | 0 | |a Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans |c Andrea Schlotterer, Henry Johannes Greten, Bjoern Andrew Remppis, Georgi Kukudov, Thomas Efferth, Jorge Machado, Per Humpert, Hans-Peter Hammes, Michael Morcos |
| 264 | 1 | |c August 2016 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.08.2019 | ||
| 520 | |a Introduction - Knowledge about the pharmacological properties of traditional TCM formulas is scarce as is their impact on aging. This study evaluated the potential effects of Sijunzi Tang Decoction (SJZTD), Si-Wu-Tang Decoction (SWTD), and Liuwei Dihuang Decoction (LWDHD) against oxidative stress and glucotoxic stress-induced neuronal dysfunction and lifespan reduction. - Methods - Nematodes (C. elegans) were cultivated under 10mmol/L paraquat or 400mmol/L glucose to assess the protective effects of a systemic Traditional Chinese Medicine (TCM) treatment. Lifespan was determined by calculation of Kaplan-Meier survival curves, formation of reactive oxygen species was quantified by hydroethidine staining, and neuronal functions were evaluated by worm tracking analysis. - Results - A 10% SJZTD solution largely normalized nematode survival under both oxidative stress (increased 3-day-survival rate by 143%) and glucotoxic stress (extended mean lifespan from 19.90 to 23.71 days). Under high glucose conditions we demonstrated both antioxidative effects (reduced Reactive Oxygen Species (ROS) formation by 71%) and neuroprotective effects (improved whole nematode motility by 179%). SWTD and LWDHD failed to confer protection in our model system. - Conclusions - The neuroprotective effects for SJZT decoction against glucotoxic stress due to pronounced antioxidant properties were demonstrated. Future studies should be extended to protection of the neurovascular system in higher organisms. | ||
| 650 | 4 | |a Anti-ageing | |
| 650 | 4 | |a Lifespan | |
| 650 | 4 | |a Neuroprotective | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a SJZT decoction | |
| 650 | 4 | |a TCM | |
| 700 | 1 | |a Humpert, Per Magnus |d 1974- |e VerfasserIn |0 (DE-588)122530748 |0 (DE-627)705941531 |0 (DE-576)293310181 |4 aut | |
| 700 | 1 | |a Hammes, Hans-Peter |d 1955- |e VerfasserIn |0 (DE-588)102028353X |0 (DE-627)691169772 |0 (DE-576)360007252 |4 aut | |
| 700 | 1 | |a Morcos, Michael |d 1966- |e VerfasserIn |0 (DE-588)1071415662 |0 (DE-627)825827272 |0 (DE-576)433067470 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of integrative medicine |d Amsterdam [u.a.] : Elsevier, 2008 |g 8(2016), 4, Seite 526-532 |h Online-Ressource |w (DE-627)587138564 |w (DE-600)2467260-9 |w (DE-576)302178449 |x 1876-3839 |7 nnas |a Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans |
| 773 | 1 | 8 | |g volume:8 |g year:2016 |g number:4 |g pages:526-532 |g extent:7 |a Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.eujim.2016.03.009 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1876382016300257 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190823 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 122530748 |a Humpert, Per Magnus |m 122530748:Humpert, Per Magnus |d 50000 |e 50000PH122530748 |k 0/50000/ |p 7 | ||
| 998 | |g 1071415662 |a Morcos, Michael |m 1071415662:Morcos, Michael |d 50000 |e 50000PM1071415662 |k 0/50000/ |p 9 |y j | ||
| 998 | |g 102028353X |a Hammes, Hans-Peter |m 102028353X:Hammes, Hans-Peter |d 60000 |d 61400 |e 60000PH102028353X |e 61400PH102028353X |k 0/60000/ |k 1/60000/61400/ |p 8 | ||
| 998 | |g 1072656302 |a Schlotterer, Andrea |m 1072656302:Schlotterer, Andrea |d 60000 |d 61400 |e 60000PS1072656302 |e 61400PS1072656302 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1671931823 |e 3508312542 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Andrea Schlotterer, Henry Johannes Greten, Bjoern Andrew Remppis, Georgi Kukudov, Thomas Efferth, Jorge Machado, Per Humpert, Hans-Peter Hammes, Michael Morcos"]},"physDesc":[{"extent":"7 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 23.08.2019"],"origin":[{"dateIssuedDisp":"August 2016","dateIssuedKey":"2016"}],"title":[{"title_sort":"Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans","title":"Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegans"}],"recId":"1671931823","language":["eng"],"id":{"eki":["1671931823"],"doi":["10.1016/j.eujim.2016.03.009"]},"relHost":[{"id":{"zdb":["2467260-9"],"eki":["587138564"],"issn":["1876-3839"]},"recId":"587138564","language":["eng"],"title":[{"title":"European journal of integrative medicine","title_sort":"European journal of integrative medicine"}],"pubHistory":["1.2008 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"2008","dateIssuedDisp":"2008-","publisher":"Elsevier"}],"part":{"year":"2016","text":"8(2016), 4, Seite 526-532","volume":"8","extent":"7","issue":"4","pages":"526-532"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Neuroprotection and antioxidative effects of Sijunzi Tang Decoction in the nematode Caenorhabditis elegansEuropean journal of integrative medicine"}],"person":[{"display":"Schlotterer, Andrea","role":"aut","roleDisplay":"VerfasserIn","family":"Schlotterer","given":"Andrea"},{"display":"Humpert, Per Magnus","given":"Per Magnus","family":"Humpert","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Hammes","given":"Hans-Peter","display":"Hammes, Hans-Peter"},{"given":"Michael","family":"Morcos","roleDisplay":"VerfasserIn","role":"aut","display":"Morcos, Michael"}]} | ||
| SRT | |a SCHLOTTERENEUROPROTE2016 | ||