Acute mountain sickness is not related to cerebral blood flow: a decompression chamber study
To evaluate the pathogenetic role of cerebral blood flow (CBF) changes occurring before and during the development of acute mountain sickness (AMS), peak mean middle cerebral artery flow velocities (V¯¯¯MCAV¯MCA<math display="inline" id="ML1" overflow="scroll" altimg...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 May 1999
|
| In: |
Journal of applied physiology
Year: 1999, Jahrgang: 86, Heft: 5, Pages: 1578-1582 |
| ISSN: | 1522-1601 |
| DOI: | 10.1152/jappl.1999.86.5.1578 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1152/jappl.1999.86.5.1578 Verlag, Volltext: https://www.physiology.org/doi/full/10.1152/jappl.1999.86.5.1578 
|
| Verfasserangaben: | Ralf W. Baumgartner, Ioakim Spyridopoulos, Peter Bärtsch, Marco Maggiorini, and Oswald Oelz |
| Zusammenfassung: | To evaluate the pathogenetic role of cerebral blood flow (CBF) changes occurring before and during the development of acute mountain sickness (AMS), peak mean middle cerebral artery flow velocities (V¯¯¯MCAV¯MCA<math display="inline" id="ML1" overflow="scroll" altimg="eq-00001.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>) were assessed by transcranial Doppler sonography in 10 subjects at 490-m altitude, and during three 12-min periods immediately (SA1), 3 (SA2), and 6 (SA3) h after decompression to a simulated altitude of 4,559 m. AMS cerebral scores increased from 0.16 ± 0.14 at baseline to 0.44 ± 0.31 at SA1, 1.11 ± 0.88 at SA2(P < 0.05), and 1.43 ± 1.03 at SA3(P < 0.01); correspondingly, three, seven, and eight subjects had AMS. Absolute and relativeV¯¯¯MCAV¯MCA<math display="inline" id="ML2" overflow="scroll" altimg="eq-00002.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math> at simulated altitude, expressed as percentages of low-altitude values (%V¯¯¯MCAV¯MCA<math display="inline" id="ML3" overflow="scroll" altimg="eq-00003.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>), did not correlate with AMS cerebral scores. Average %V¯¯¯MCAV¯MCA<math display="inline" id="ML4" overflow="scroll" altimg="eq-00004.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math> remained unchanged, because %V¯¯¯MCAV¯MCA<math display="inline" id="ML5" overflow="scroll" altimg="eq-00005.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>increased in three and remained unchanged or decreased in seven subjects at SA2 and SA3. These results suggest that CBF is not important in the pathogenesis of AMS and shows substantial interindividual differences during the first hours at simulated altitude. |
|---|---|
| Beschreibung: | Gesehen am 27.08.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1522-1601 |
| DOI: | 10.1152/jappl.1999.86.5.1578 |