Beta-blockers and ACE inhibitors are associated with improved survival secondary to ventricular tachyarrhythmia
Objective: The study sought to assess the impact of treatment with beta-blocker (BB) or ACE inhibitor/angiotensin receptor blocker (ACEi/ARB) on secondary survival in patients presenting with ventricular tachyarrhythmia. Background: Data regarding outcome of patients presenting with ventricular tach...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 August 2018
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| In: |
Cardiovascular drugs and therapy
Year: 2018, Jahrgang: 32, Heft: 4, Pages: 353-363 |
| ISSN: | 1573-7241 |
| DOI: | 10.1007/s10557-018-6812-z |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s10557-018-6812-z
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| Verfasserangaben: | Tobias Schupp, Michael Behnes, Christel Weiß, Christoph Nienaber, Siegfried Lang, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin |
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| 245 | 1 | 0 | |a Beta-blockers and ACE inhibitors are associated with improved survival secondary to ventricular tachyarrhythmia |c Tobias Schupp, Michael Behnes, Christel Weiß, Christoph Nienaber, Siegfried Lang, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin |
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| 520 | |a Objective: The study sought to assess the impact of treatment with beta-blocker (BB) or ACE inhibitor/angiotensin receptor blocker (ACEi/ARB) on secondary survival in patients presenting with ventricular tachyarrhythmia. Background: Data regarding outcome of patients presenting with ventricular tachyarrhythmia treated with BB and ACEi/ARB is limited. Methods: A large retrospective registry was used including consecutive patients presenting with ventricular tachycardia and fibrillation from 2002 to 2016 on admission. Applying propensity-score matching for harmonization, the impact of “BB” and “ACEi/ARB” was comparatively evaluated. The primary prognostic outcome was long-term all-cause death at 3 years. Results: A total of 972 matched patients were included. Both patients with BB (long-term mortality rate 18 versus 27%; log rank p = 0.041; HR = 0.661; 95% CI = 0.443-0.986; p = 0.043) and with ACEi/ARB (long-term mortality rate 13 versus 23%; log rank p = 0.004; HR = 0.544; 95% CI = 0.359-0.824; p = 0.004) revealed better secondary survival compared to patients without after presenting with ventricular tachyarrhythmia on admission. The prognostic benefit of BB was comparable to ACEi/ARB (long-term mortality rate 21 versus 26%; log rank p = 0.539). Conclusion: BB and ACEi/ARB were associated with improved secondary survival in patients surviving ventricular tachyarrhythmia on admission. | ||
| 650 | 4 | |a ACE inhibitor | |
| 650 | 4 | |a Angiotensin receptor blocker | |
| 650 | 4 | |a Beta-blocker | |
| 650 | 4 | |a Medical treatment | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Pharmacological drugs | |
| 650 | 4 | |a Sudden cardiac death | |
| 650 | 4 | |a Ventricular fibrillation | |
| 650 | 4 | |a Ventricular tachycardia | |
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