Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study)
Background: Anemia has been shown to be a risk factor for coronary artery disease (CAD) and mortality, whereas the role of iron metabolism remains controversial. Methods: We analyzed iron metabolism and its associations with cardiovascular death and total mortality in patients undergoing coronary an...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
|
| In: |
Clinical chemistry
Year: 2019, Volume: 65, Issue: 7, Pages: ? |
| ISSN: | 1530-8561 |
| DOI: | 10.1373/clinchem.2018.297242 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1373/clinchem.2018.297242 Verlag, kostenfrei, Volltext: http://clinchem.aaccjnls.org/content/early/2019/03/26/clinchem.2018.297242 
|
| Author Notes: | Tanja B. Grammer, Hubert Scharnagl, Alexander Dressel, Marcus E. Kleber, Günther Silbernagel, Stefan Pilz, Andreas Tomaschitz, Wolfgang Koenig, Bertram Mueller-Myhsok, Winfried März and Pavel Strnad |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1672408067 | ||
| 003 | DE-627 | ||
| 005 | 20250818113746.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190829s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1373/clinchem.2018.297242 |2 doi | |
| 035 | |a (DE-627)1672408067 | ||
| 035 | |a (DE-599)KXP1672408067 | ||
| 035 | |a (OCoLC)1341238763 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Grammer, Tanja B. |d 1972- |e VerfasserIn |0 (DE-588)1030134952 |0 (DE-627)734830041 |0 (DE-576)377941018 |4 aut | |
| 245 | 1 | 0 | |a Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study) |c Tanja B. Grammer, Hubert Scharnagl, Alexander Dressel, Marcus E. Kleber, Günther Silbernagel, Stefan Pilz, Andreas Tomaschitz, Wolfgang Koenig, Bertram Mueller-Myhsok, Winfried März and Pavel Strnad |
| 264 | 1 | |c 2019 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.08.2019 | ||
| 500 | |a published March 27, 2019 | ||
| 520 | |a Background: Anemia has been shown to be a risk factor for coronary artery disease (CAD) and mortality, whereas the role of iron metabolism remains controversial. Methods: We analyzed iron metabolism and its associations with cardiovascular death and total mortality in patients undergoing coronary angiography with a median follow-up of 9.9 years. Hemoglobin and iron status were determined in 1480 patients with stable CAD and in 682 individuals in whom significant CAD had been excluded by angiography. Results: Multivariate-adjusted hazard ratios (HRs) for total mortality in the lowest quartiles of iron, transferrin saturation, ferritin, soluble transferrin receptor (sTfR), and hemoglobin were 1.22 (95% CI, 0.96-1.60), 1.23 (95% CI, 0.97-1.56), 1.27 (95% CI, 1.02-1.58), 1.26 (95% CI, 0.97-1.65), and 0.99 (95% CI, 0.79-1.24), respectively, compared to the second or third quartile, which served as reference because of a J-shaped association. The corresponding HRs for total mortality in the highest quartiles were 1.44 (95% CI, 1.10-1.87), 1.37 (95% CI, 1.05-1.77), 1.17 (95% CI, 0.92-1.50), 1.76 (95% CI, 1.39-2.22), and 0.83 (95% CI, 0.63-1.09) compared to the second quartile. HRs for cardiovascular death were similar. For hepcidin, the adjusted HRs for total mortality and cardiovascular deaths were 0.62 (95% CI, 0.49-0.78) and 0.70 (95% CI, 0.52-0.90) in the highest quartile compared to the lowest one. Conclusions: In stable patients undergoing angiography, serum iron, transferrin saturation, sTfR, and ferritin had J-shaped associations and hemoglobin only a marginal association with cardiovascular and total mortality. Hepcidin was continuously and inversely related to mortality. | ||
| 700 | 1 | |a Scharnagl, Hubert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dressel, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleber, Marcus E. |d 1974- |e VerfasserIn |0 (DE-588)1030135177 |0 (DE-627)734830440 |0 (DE-576)377941379 |4 aut | |
| 700 | 1 | |a Silbernagel, Günther |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pilz, Stefan |e VerfasserIn |0 (DE-588)121523756 |0 (DE-627)705511073 |0 (DE-576)292753683 |4 aut | |
| 700 | 1 | |a Tomaschitz, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koenig, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mueller-Myhsok, Bertram |e VerfasserIn |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Strnad, Pavel |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical chemistry |d Washington, DC : American Association for Clinical Chemistry, 1955 |g 65(2019), 7, Seite ? |h Online-Ressource |w (DE-627)266883117 |w (DE-600)1468161-4 |w (DE-576)075146401 |x 1530-8561 |7 nnas |a Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study) |
| 773 | 1 | 8 | |g volume:65 |g year:2019 |g number:7 |g pages:? |g extent:13 |a Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study) |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1373/clinchem.2018.297242 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://clinchem.aaccjnls.org/content/early/2019/03/26/clinchem.2018.297242 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190829 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 60000 |d 61400 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/60000/ |k 1/60000/61400/ |p 10 | ||
| 998 | |g 1030135177 |a Kleber, Marcus E. |m 1030135177:Kleber, Marcus E. |d 60000 |d 61400 |e 60000PK1030135177 |e 61400PK1030135177 |k 0/60000/ |k 1/60000/61400/ |p 4 | ||
| 998 | |g 1030134952 |a Grammer, Tanja B. |m 1030134952:Grammer, Tanja B. |d 60000 |d 65300 |e 60000PG1030134952 |e 65300PG1030134952 |k 0/60000/ |k 1/60000/65300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1672408067 |e 3509551737 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Grammer, Tanja B.","role":"aut","family":"Grammer","given":"Tanja B."},{"role":"aut","display":"Scharnagl, Hubert","given":"Hubert","family":"Scharnagl"},{"family":"Dressel","given":"Alexander","display":"Dressel, Alexander","role":"aut"},{"given":"Marcus E.","family":"Kleber","role":"aut","display":"Kleber, Marcus E."},{"display":"Silbernagel, Günther","role":"aut","family":"Silbernagel","given":"Günther"},{"display":"Pilz, Stefan","role":"aut","family":"Pilz","given":"Stefan"},{"family":"Tomaschitz","given":"Andreas","display":"Tomaschitz, Andreas","role":"aut"},{"display":"Koenig, Wolfgang","role":"aut","family":"Koenig","given":"Wolfgang"},{"display":"Mueller-Myhsok, Bertram","role":"aut","family":"Mueller-Myhsok","given":"Bertram"},{"family":"März","given":"Winfried","display":"März, Winfried","role":"aut"},{"display":"Strnad, Pavel","role":"aut","family":"Strnad","given":"Pavel"}],"language":["eng"],"title":[{"title_sort":"Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study)","title":"Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study)"}],"relHost":[{"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Clinical chemistry","subtitle":"journal of the American Association for Clinical Chemistry ; international journal of laboratory medicine and molecular diagnostics","title":"Clinical chemistry"}],"disp":"Iron metabolism, hepcidin, and mortality (the Ludwigshafen Risk and Cardiovascular Health Study)Clinical chemistry","note":["Gesehen am 26.08.2021"],"corporate":[{"display":"American Association of Clinical Chemists","role":"isb"}],"id":{"eki":["266883117"],"issn":["1530-8561"],"zdb":["1468161-4"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"7","pages":"?","text":"65(2019), 7, Seite ?","volume":"65","year":"2019","extent":"13"},"pubHistory":["1.1955 -"],"recId":"266883117","origin":[{"dateIssuedDisp":"1955-","publisher":"American Association for Clinical Chemistry ; Oxford University Press","dateIssuedKey":"1955","publisherPlace":"Washington, DC ; Oxford"}]}],"physDesc":[{"extent":"13 S."}],"id":{"eki":["1672408067"],"doi":["10.1373/clinchem.2018.297242"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 29.08.2019","published March 27, 2019"],"recId":"1672408067","name":{"displayForm":["Tanja B. Grammer, Hubert Scharnagl, Alexander Dressel, Marcus E. Kleber, Günther Silbernagel, Stefan Pilz, Andreas Tomaschitz, Wolfgang Koenig, Bertram Mueller-Myhsok, Winfried März and Pavel Strnad"]},"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}]} | ||
| SRT | |a GRAMMERTANIRONMETABO2019 | ||