The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients: a meta-analysis based on individual patient data from randomised controlled trials
Objective: Prognostic value of health-related quality of life (HRQoL) data may be important to inform patients in clinical practice and to guide clinical decision-making. Our study investigated the added prognostic value of HRQoL for overall survival (OS) and progression-free survival (PFS) in a lar...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 June 2019
|
| In: |
European journal of cancer
Year: 2019, Volume: 116, Pages: 190-198 |
| ISSN: | 1879-0852 |
| DOI: | 10.1016/j.ejca.2019.05.012 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejca.2019.05.012 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0959804919303156 
|
| Author Notes: | Marijke Coomans, Linda Dirven, Neil K. Aaronson, Brigitta G. Baumert, Martin van den Bent, Andrew Bottomley, Alba A. Brandes, Olivier Chinot, Corneel Coens, Thierry Gorlia, Ulrich Herrlinger, Florence Keime-Guibert, Annika Malmström, Francesca Martinelli, Roger Stupp, Andrea Talacchi, Michael Weller, Wolfgang Wick, Jaap C. Reijneveld, Martin J. B. Taphoorn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1675671575 | ||
| 003 | DE-627 | ||
| 005 | 20220816215647.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190902s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejca.2019.05.012 |2 doi | |
| 035 | |a (DE-627)1675671575 | ||
| 035 | |a (DE-599)KXP1675671575 | ||
| 035 | |a (OCoLC)1341238716 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Coomans, Marijke |e VerfasserIn |0 (DE-588)1193934907 |0 (DE-627)1675671850 |4 aut | |
| 245 | 1 | 4 | |a The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients |b a meta-analysis based on individual patient data from randomised controlled trials |c Marijke Coomans, Linda Dirven, Neil K. Aaronson, Brigitta G. Baumert, Martin van den Bent, Andrew Bottomley, Alba A. Brandes, Olivier Chinot, Corneel Coens, Thierry Gorlia, Ulrich Herrlinger, Florence Keime-Guibert, Annika Malmström, Francesca Martinelli, Roger Stupp, Andrea Talacchi, Michael Weller, Wolfgang Wick, Jaap C. Reijneveld, Martin J. B. Taphoorn |
| 264 | 1 | |c 13 June 2019 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.09.2019 | ||
| 520 | |a Objective: Prognostic value of health-related quality of life (HRQoL) data may be important to inform patients in clinical practice and to guide clinical decision-making. Our study investigated the added prognostic value of HRQoL for overall survival (OS) and progression-free survival (PFS) in a large heterogeneous sample of glioma patients, besides known prognostic factors. Methods: We included individual baseline data from previously published randomised controlled trials (RCTs) in glioma patients in which HRQoL was assessed through the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-BN20 questionnaires. Multivariable Cox regression models (stratified for newly diagnosed versus recurrent disease) were constructed, first with clinical variables (age, sex, tumour type, performance status, allocated treatment and extent of resection) only and subsequently with HRQoL variables added, separately for OS and PFS. The added prognostic value of HRQoL was calculated using C-indices. Results: Baseline HRQoL and clinical data from 15 RCTs were included, comprising 5217 patients. In the model including both clinical and HRQoL variables, better cognitive and role functioning and less motor dysfunction were independently associated with longer OS, whereas better role and cognitive functioning, less nausea and vomiting and more appetite loss were independently associated with prolonged PFS. However, C-indices indicated only a small prognostic improvement of the models for OS and PFS when adding HRQoL to the clinical prognostic variables (+1.1% for OS and +.7% for PFS). Conclusion: Our findings demonstrate that several baseline HRQoL variables are independently prognostic for OS and PFS, yet the added value of HRQoL to the known clinical prognostic variables was small. | ||
| 650 | 4 | |a Brain tumour | |
| 650 | 4 | |a Glioma | |
| 650 | 4 | |a Health-related quality of life (HRQoL) | |
| 650 | 4 | |a Prognostic factor | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Dirven, Linda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Aaronson, Neil K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baumert, Brigitta G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a van den Bent, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bottomley, Andrew |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brandes, Alba A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chinot, Olivier |e VerfasserIn |4 aut | |
| 700 | 1 | |a Coens, Corneel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gorlia, Thierry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrlinger, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Keime-Guibert, Florence |e VerfasserIn |4 aut | |
| 700 | 1 | |a Malmström, Annika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martinelli, Francesca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stupp, Roger |e VerfasserIn |4 aut | |
| 700 | 1 | |a Talacchi, Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weller, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Reijneveld, Jaap C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Taphoorn, Martin J. B. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cancer |d Amsterdam [u.a.] : Elsevier, 1992 |g 116(2019), Seite 190-198 |w (DE-627)266883400 |w (DE-600)1468190-0 |w (DE-576)090954173 |x 1879-0852 |7 nnas |a The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients a meta-analysis based on individual patient data from randomised controlled trials |
| 773 | 1 | 8 | |g volume:116 |g year:2019 |g pages:190-198 |g extent:9 |a The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients a meta-analysis based on individual patient data from randomised controlled trials |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ejca.2019.05.012 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0959804919303156 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190902 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 18 | ||
| 999 | |a KXP-PPN1675671575 |e 3510839153 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"13 June 2019","dateIssuedKey":"2019"}],"name":{"displayForm":["Marijke Coomans, Linda Dirven, Neil K. Aaronson, Brigitta G. Baumert, Martin van den Bent, Andrew Bottomley, Alba A. Brandes, Olivier Chinot, Corneel Coens, Thierry Gorlia, Ulrich Herrlinger, Florence Keime-Guibert, Annika Malmström, Francesca Martinelli, Roger Stupp, Andrea Talacchi, Michael Weller, Wolfgang Wick, Jaap C. Reijneveld, Martin J. B. Taphoorn"]},"id":{"eki":["1675671575"],"doi":["10.1016/j.ejca.2019.05.012"]},"recId":"1675671575","type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Marijke","display":"Coomans, Marijke","role":"aut","family":"Coomans"},{"display":"Dirven, Linda","family":"Dirven","role":"aut","given":"Linda"},{"display":"Aaronson, Neil K.","role":"aut","family":"Aaronson","given":"Neil K."},{"given":"Brigitta G.","display":"Baumert, Brigitta G.","family":"Baumert","role":"aut"},{"role":"aut","family":"van den Bent","display":"van den Bent, Martin","given":"Martin"},{"role":"aut","family":"Bottomley","display":"Bottomley, Andrew","given":"Andrew"},{"family":"Brandes","role":"aut","display":"Brandes, Alba A.","given":"Alba A."},{"given":"Olivier","display":"Chinot, Olivier","role":"aut","family":"Chinot"},{"given":"Corneel","display":"Coens, Corneel","family":"Coens","role":"aut"},{"display":"Gorlia, Thierry","family":"Gorlia","role":"aut","given":"Thierry"},{"family":"Herrlinger","role":"aut","display":"Herrlinger, Ulrich","given":"Ulrich"},{"family":"Keime-Guibert","role":"aut","display":"Keime-Guibert, Florence","given":"Florence"},{"given":"Annika","display":"Malmström, Annika","role":"aut","family":"Malmström"},{"role":"aut","family":"Martinelli","display":"Martinelli, Francesca","given":"Francesca"},{"given":"Roger","family":"Stupp","role":"aut","display":"Stupp, Roger"},{"given":"Andrea","family":"Talacchi","role":"aut","display":"Talacchi, Andrea"},{"display":"Weller, Michael","role":"aut","family":"Weller","given":"Michael"},{"given":"Wolfgang","display":"Wick, Wolfgang","family":"Wick","role":"aut"},{"given":"Jaap C.","role":"aut","family":"Reijneveld","display":"Reijneveld, Jaap C."},{"display":"Taphoorn, Martin J. B.","family":"Taphoorn","role":"aut","given":"Martin J. B."}],"note":["Gesehen am 02.09.2019"],"language":["eng"],"physDesc":[{"extent":"9 S."}],"title":[{"subtitle":"a meta-analysis based on individual patient data from randomised controlled trials","title_sort":"added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients","title":"The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients"}],"relHost":[{"part":{"text":"116(2019), Seite 190-198","year":"2019","pages":"190-198","volume":"116","extent":"9"},"title":[{"title":"European journal of cancer","title_sort":"European journal of cancer"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"266883400","id":{"eki":["266883400"],"zdb":["1468190-0"],"issn":["1879-0852"]},"corporate":[{"display":"European Organization for Research on Treatment of Cancer","role":"isb"},{"display":"European Association for Cancer Research","role":"isb"},{"role":"isb","display":"European School of Oncology"}],"origin":[{"publisher":"Elsevier ; Pergamon Press","publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1992","dateIssuedDisp":"1992-"}],"disp":"The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients a meta-analysis based on individual patient data from randomised controlled trialsEuropean journal of cancer","language":["eng"],"note":["Gesehen am 21.03.24","Ungezählte Beil.: Supplement"],"pubHistory":["28.1992 -"],"titleAlt":[{"title":"EJC online"}]}]} | ||
| SRT | |a COOMANSMARADDEDVALUE1320 | ||