A variational approach to optimal two-stage designs
Recalculating the sample size in adaptive two-stage designs is a well-established method to gain flexibility in a clinical trial. Jennison and Turnbull (2015) proposed an “optimal” adaptive two-stage design based on the inverse normal combination test, which minimizes a mixed criterion of expected s...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 July 2019
|
| In: |
Statistics in medicine
Year: 2019, Jahrgang: 38, Heft: 21, Pages: 4159-4171 |
| ISSN: | 1097-0258 |
| DOI: | 10.1002/sim.8291 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/sim.8291 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.8291 
|
| Verfasserangaben: | Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1675682275 | ||
| 003 | DE-627 | ||
| 005 | 20240206075327.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190902s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/sim.8291 |2 doi | |
| 035 | |a (DE-627)1675682275 | ||
| 035 | |a (DE-599)KXP1675682275 | ||
| 035 | |a (OCoLC)1341241578 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pilz, Maximilian |d 1993- |e VerfasserIn |0 (DE-588)1193938732 |0 (DE-627)1675681511 |4 aut | |
| 245 | 1 | 2 | |a A variational approach to optimal two-stage designs |c Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser |
| 264 | 1 | |c 01 July 2019 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.09.2019 | ||
| 520 | |a Recalculating the sample size in adaptive two-stage designs is a well-established method to gain flexibility in a clinical trial. Jennison and Turnbull (2015) proposed an “optimal” adaptive two-stage design based on the inverse normal combination test, which minimizes a mixed criterion of expected sample size under the alternative and conditional power. We demonstrate that the use of a combination test is not necessary to control the type one error rate and use variational techniques to develop a general adaptive design that is globally optimal under predefined optimality criteria. This approach yields to more efficient designs and furthermore allows to investigate the efficiency of the inverse normal method and the relation between local (interim-based) recalculation rules and global (unconditional) optimality of adaptive two-stage designs. | ||
| 650 | 4 | |a adaptive design | |
| 650 | 4 | |a clinical trial | |
| 650 | 4 | |a inverse normal combination test | |
| 650 | 4 | |a optimal design | |
| 650 | 4 | |a sample size calculation | |
| 700 | 1 | |a Kunzmann, Kevin |d 1988- |e VerfasserIn |0 (DE-588)1109931751 |0 (DE-627)86460789X |0 (DE-576)475679687 |4 aut | |
| 700 | 1 | |a Herrmann, Carolin |e VerfasserIn |0 (DE-588)121051401X |0 (DE-627)1698554737 |4 aut | |
| 700 | 1 | |a Rauch, Geraldine |e VerfasserIn |0 (DE-588)139823492 |0 (DE-627)61378944X |0 (DE-576)313422923 |4 aut | |
| 700 | 1 | |a Kieser, Meinhard |d 1960- |e VerfasserIn |0 (DE-588)103276547X |0 (DE-627)739277766 |0 (DE-576)168963825 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Statistics in medicine |d Chichester [u.a.] : Wiley, 1982 |g 38(2019), 21, Seite 4159-4171 |h Online-Ressource |w (DE-627)30246719X |w (DE-600)1491221-1 |w (DE-576)079719686 |x 1097-0258 |7 nnas |a A variational approach to optimal two-stage designs |
| 773 | 1 | 8 | |g volume:38 |g year:2019 |g number:21 |g pages:4159-4171 |g extent:13 |a A variational approach to optimal two-stage designs |
| 856 | 4 | 0 | |u https://doi.org/10.1002/sim.8291 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.8291 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190902 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 103276547X |a Kieser, Meinhard |m 103276547X:Kieser, Meinhard |d 910000 |d 999701 |e 910000PK103276547X |e 999701PK103276547X |k 0/910000/ |k 1/910000/999701/ |p 5 |y j | ||
| 998 | |g 139823492 |a Rauch, Geraldine |m 139823492:Rauch, Geraldine |d 50000 |e 50000PR139823492 |k 0/50000/ |p 4 | ||
| 998 | |g 1109931751 |a Kunzmann, Kevin |m 1109931751:Kunzmann, Kevin |d 910000 |d 999701 |e 910000PK1109931751 |e 999701PK1109931751 |k 0/910000/ |k 1/910000/999701/ | ||
| 998 | |g 1193938732 |a Pilz, Maximilian |m 1193938732:Pilz, Maximilian |d 910000 |d 999701 |e 910000PP1193938732 |e 999701PP1193938732 |k 0/910000/ |k 1/910000/999701/ |p 1 |x j | ||
| 999 | |a KXP-PPN1675682275 |e 3510862643 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1675682275"],"doi":["10.1002/sim.8291"]},"recId":"1675682275","name":{"displayForm":["Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser"]},"relHost":[{"note":["Gesehen am 28.02.08"],"pubHistory":["1.1982 -"],"title":[{"title_sort":"Statistics in medicine","title":"Statistics in medicine"}],"origin":[{"publisherPlace":"Chichester [u.a.]","dateIssuedDisp":"1982-","publisher":"Wiley","dateIssuedKey":"1982"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"text":"38(2019), 21, Seite 4159-4171","year":"2019","issue":"21","extent":"13","volume":"38","pages":"4159-4171"},"disp":"A variational approach to optimal two-stage designsStatistics in medicine","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"eki":["30246719X"],"doi":["10.1002/(ISSN)1097-0258"],"zdb":["1491221-1"],"issn":["1097-0258"]},"recId":"30246719X"}],"physDesc":[{"extent":"13 S."}],"language":["eng"],"title":[{"title":"A variational approach to optimal two-stage designs","title_sort":"variational approach to optimal two-stage designs"}],"person":[{"display":"Pilz, Maximilian","given":"Maximilian","family":"Pilz","role":"aut"},{"role":"aut","given":"Kevin","family":"Kunzmann","display":"Kunzmann, Kevin"},{"role":"aut","family":"Herrmann","given":"Carolin","display":"Herrmann, Carolin"},{"family":"Rauch","given":"Geraldine","display":"Rauch, Geraldine","role":"aut"},{"display":"Kieser, Meinhard","given":"Meinhard","family":"Kieser","role":"aut"}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"01 July 2019"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 02.09.2019"]} | ||
| SRT | |a PILZMAXIMIVARIATIONA0120 | ||