Lectinology 4.0: altering modular (ga)lectin display for functional analysis and biomedical applications
BACKGROUND: Recognition of glycans by lectins is emerging as (patho)physiologically broadly used mode of cellular information transfer. Whereas the direct ligand-receptor contact is often already thoroughly characterized, the functional relevance of aspects of architecture such as modular design and...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 March 2019
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| In: |
Biochimica et biophysica acta. Specialized section on biophysical subjects
Year: 2019, Volume: 1863, Issue: 5, Pages: 935-940 |
| ISSN: | 0926-6577 |
| DOI: | 10.1016/j.bbagen.2019.03.005 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.bbagen.2019.03.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0304416519300558 
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| Author Notes: | Anna-Kristin Ludwig, Herbert Kaltner, Jürgen Kopitz, Hans-Joachim Gabius |
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| 520 | |a BACKGROUND: Recognition of glycans by lectins is emerging as (patho)physiologically broadly used mode of cellular information transfer. Whereas the direct ligand-receptor contact is often already thoroughly characterized, the functional relevance of aspects of architecture such as modular design and valence of lectins is less well defined. - SCOPE OF REVIEW: Following an introduction to modular lectin design, three levels of methodology are then reviewed that delineate lectin structure-activity relationships beyond glycan binding, with emphasis on domain shuffling. - MAJOR CONCLUSIONS: Engineering of variants by modular transplantation facilitates versatile Nature-inspired design switches and access to new combinations with translational potential, as exemplified for human adhesion/growth-regulatory galectins. - GENERAL SIGNIFICANCE: To gain an understanding of the functional significance of natural variations in quaternary structure and modular design within a protein family is a current challenge. Strategic application of methods of the described phases is a means to respond to this challenge. | ||
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