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Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios

In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. This work compares the predictions of three of the main radio-...

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Bibliographic Details
Main Authors: Giovannini, Giulia (Author) , Bauer, Julia (Author) , Tessonnier, Thomas (Author) , Debus, Jürgen (Author) , Mairani, Andrea (Author) , Parodi, Katia (Author)
Format: Article (Journal)
Language:English
Published: 17 May 2016
In: Radiation oncology
Year: 2016, Volume: 11, Issue: 1
ISSN:1748-717X
DOI:10.1186/s13014-016-0642-6
Online Access:Verlag, Volltext: https://doi.org/10.1186/s13014-016-0642-6
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Author Notes:Giulia Giovannini, Till Böhlen, Gonzalo Cabal, Julia Bauer, Thomas Tessonnier, Kathrin Frey, Jürgen Debus, Andrea Mairani and Katia Parodi
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Summary:In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. This work compares the predictions of three of the main radio-biological models proposed in the literature by Carabe-Fernandez, Wedenberg, Scholz and coworkers.
Item Description:Gesehen am 10.09.2019
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-016-0642-6

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