Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios
In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. This work compares the predictions of three of the main radio-...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 May 2016
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| In: |
Radiation oncology
Year: 2016, Jahrgang: 11, Heft: 1 |
| ISSN: | 1748-717X |
| DOI: | 10.1186/s13014-016-0642-6 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1186/s13014-016-0642-6 |
| Verfasserangaben: | Giulia Giovannini, Till Böhlen, Gonzalo Cabal, Julia Bauer, Thomas Tessonnier, Kathrin Frey, Jürgen Debus, Andrea Mairani and Katia Parodi |
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| 520 | |a In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. This work compares the predictions of three of the main radio-biological models proposed in the literature by Carabe-Fernandez, Wedenberg, Scholz and coworkers. | ||
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