Perilipin 1 expression differentiates liposarcoma from other types of soft tissue sarcoma
Lipid droplets, a morphologic feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT (perilipin, adipophilin, and tail-interacting protein of 47 kD) family. So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has only be...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 May 2019
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| In: |
The American journal of pathology
Year: 2019, Volume: 189, Issue: 8, Pages: 1547-1558 |
| ISSN: | 1525-2191 |
| DOI: | 10.1016/j.ajpath.2019.04.017 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.ajpath.2019.04.017 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0002944018307016 
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| Author Notes: | Beate K. Straub, Hagen R. Witzel, Lena M. Pawella, Marcus Renner, Eva Eiteneuer, Merita Hashani, Peter Schirmacher, Wilfried Roth, and Gunhild Mechtersheimer |
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| 520 | |a Lipid droplets, a morphologic feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT (perilipin, adipophilin, and tail-interacting protein of 47 kD) family. So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has only been studied in a few cases. The aim of this study was to investigate the expression of perilipins in 478 human soft tissue tumors and 60 respective normal tissues. Perilipin 1 was immunohistochemically positive in all studied cases of well-differentiated liposarcomas, >90% of myxoid round cell liposarcomas, and >70% of pleomorphic liposarcomas, whereas only the differentiated components of dedifferentiated liposarcomas were immunohistochemically positive for perilipin 1. All other types of soft tissue sarcomas were negative for perilipin 1. Perilipin 2 was more prominent in dedifferentiated and pleomorphic liposarcomas and nearly all other high-grade sarcomas. In well-differentiated liposarcomas, lipomas, or normal adipose tissue, perilipin 2 was virtually absent. In addition, long-term stimulation of adipogenesis in the liposarcoma cell line LiSa-2 restored perilipin 1 expression, as exhibited in the source tumor. Furthermore, knockdown of perilipin 2 or perilipin 3 in LiSa-2 cells influenced lipid droplet number and size as well as cell vitality. In summary, perilipin 1 is a promising marker for the differential diagnosis of liposarcomas from other soft tissue sarcomas, whereas perilipin 2 correlates negatively with tumor grade and may be therapeutically useful. | ||
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