Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial
BackgroundThe Fit fOR The Aged (FORTA) list, a drug classification combining positive and negative labelling of drugs, has been clinically (VALFORTA-trial) validated to improve medication quality and clinical endpoints.ObjectiveThe objective of this study was to determine the association of medicati...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
Drugs & aging
Year: 2019, Jahrgang: 36, Heft: 3, Pages: 269-277 |
| ISSN: | 1179-1969 |
| DOI: | 10.1007/s40266-018-0626-3 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s40266-018-0626-3 Verlag, Volltext: https://link.springer.com/article/10.1007%2Fs40266-018-0626-3 
|
| Verfasserangaben: | Farhad Pazan, Heinrich Burkhardt, Helmut Frohnhofen, Christel Weiss, Christina Throm, Alexandra Kuhn-Thiel, Martin Wehling |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1676783938 | ||
| 003 | DE-627 | ||
| 005 | 20230428155056.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190912s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s40266-018-0626-3 |2 doi | |
| 035 | |a (DE-627)1676783938 | ||
| 035 | |a (DE-599)KXP1676783938 | ||
| 035 | |a (OCoLC)1341242953 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pazan, Farhad |d 1980- |e VerfasserIn |0 (DE-588)116216302X |0 (DE-627)102561416X |0 (DE-576)507240219 |4 aut | |
| 245 | 1 | 0 | |a Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial |c Farhad Pazan, Heinrich Burkhardt, Helmut Frohnhofen, Christel Weiss, Christina Throm, Alexandra Kuhn-Thiel, Martin Wehling |
| 264 | 1 | |c 2019 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 21 December 2018 | ||
| 500 | |a Gesehen am 12.09.2019 | ||
| 520 | |a BackgroundThe Fit fOR The Aged (FORTA) list, a drug classification combining positive and negative labelling of drugs, has been clinically (VALFORTA-trial) validated to improve medication quality and clinical endpoints.ObjectiveThe objective of this study was to determine the association of medication quality with functional abilities tested in cognitive and physical function tests.Patients and MethodsData from the prospective, randomized controlled VALFORTA trial on 409 geriatric (mean age 81.53 years) in-hospital patients were tested for associations between the FORTA score (sum of over- and under-treatment errors) on admission and cognitive and physical function tests. Univariate and multivariate linear correlations corrected for age, sex, number of medications, number of chronic conditions, and body mass index as well as comparisons between high and low FORTA-score (cut-off 3) patients were performed.ResultsThe FORTA score was significantly correlated with Instrumental Activities of Daily Living (p < 0.0001), the Tinetti test (p < 0.002), Essen Questionnaire on Age and Sleepiness (p < 0.0001), Mini-Mental State Examination (p < 0.0001), and handgrip strength (p < 0.04) in the univariate analysis, and with Instrumental Activities of Daily Living (p < 0.003), the Tinetti test (p < 0.003), and the Essen Questionnaire on Age and Sleepiness (p < 0.0001) in the multivariate analysis. Effect size was weak for Instrumental Activities of Daily Living (R-squared = 0.12) and the Tinetti test (R-squared = 0.03) and medium for the Essen Questionnaire on Age and Sleepiness (R-squared = 0.22). Significant differences between patients with high and low FORTA scores were found for Instrumental Activities of Daily Living, the Tinetti test, mini-nutritional assessments, Mini-Mental State Examination, Essen Questionnaire on Age and Sleepiness, and the Geriatric Depression Scale. All significant tests revealed that higher FORTA scores (lower medication quality) were associated with less favorable test outcomes.ConclusionsThe FORTA score is associated with relevant aspects of comprehensive geriatric assessment, underlining the importance of medication quality for the functional and cognitive well-being of older patients.Trial Registration NumberDRKS00000531. | ||
| 700 | 1 | |a Burkhardt, Heinrich |d 1962- |e VerfasserIn |0 (DE-588)141180188 |0 (DE-627)625414624 |0 (DE-576)322588332 |4 aut | |
| 700 | 1 | |a Weiß, Christel |d 1958- |e VerfasserIn |0 (DE-588)123287707 |0 (DE-627)082463417 |0 (DE-576)168356104 |4 aut | |
| 700 | 1 | |a Wehling, Martin |d 1957- |e VerfasserIn |0 (DE-588)129939331 |0 (DE-627)484463152 |0 (DE-576)297912577 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Drugs & aging |d Berlin [u.a.] : Springer, 1991 |g 36(2019), 3, Seite 269-277 |h Online-Ressource |w (DE-627)327644281 |w (DE-600)2043689-0 |w (DE-576)273880810 |x 1179-1969 |7 nnas |a Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial |
| 773 | 1 | 8 | |g volume:36 |g year:2019 |g number:3 |g pages:269-277 |g extent:9 |a Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s40266-018-0626-3 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007%2Fs40266-018-0626-3 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190912 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 129939331 |a Wehling, Martin |m 129939331:Wehling, Martin |d 60000 |d 65400 |e 60000PW129939331 |e 65400PW129939331 |k 0/60000/ |k 1/60000/65400/ |p 7 |y j | ||
| 998 | |g 123287707 |a Weiß, Christel |m 123287707:Weiß, Christel |d 60000 |d 60200 |d 60250 |e 60000PW123287707 |e 60200PW123287707 |e 60250PW123287707 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60250/ |p 4 | ||
| 998 | |g 141180188 |a Burkhardt, Heinrich |m 141180188:Burkhardt, Heinrich |d 60000 |d 65400 |e 60000PB141180188 |e 65400PB141180188 |k 0/60000/ |k 1/60000/65400/ |p 2 | ||
| 998 | |g 116216302X |a Pazan, Farhad |m 116216302X:Pazan, Farhad |d 60000 |d 65400 |e 60000PP116216302X |e 65400PP116216302X |k 0/60000/ |k 1/60000/65400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1676783938 |e 3514707545 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"9 S."}],"recId":"1676783938","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Published online: 21 December 2018","Gesehen am 12.09.2019"],"title":[{"title_sort":"Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial","title":"Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trial"}],"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"relHost":[{"id":{"eki":["327644281"],"issn":["1179-1969"],"zdb":["2043689-0"]},"part":{"year":"2019","volume":"36","pages":"269-277","extent":"9","text":"36(2019), 3, Seite 269-277","issue":"3"},"pubHistory":["1.1991 -"],"titleAlt":[{"title":"Drugs and aging"}],"title":[{"title_sort":"Drugs & aging","title":"Drugs & aging","subtitle":"evaluations of age-related changes in drug disposition and drug therapy in the elderly"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"note":["Gesehen am 23.04.14"],"origin":[{"publisher":"Springer ; Adis Intern.","dateIssuedKey":"1991","dateIssuedDisp":"1991-","publisherPlace":"Berlin [u.a.] ; Auckland [u.a.]"}],"disp":"Higher Fit-fOR-The-Aged (FORTA) scores comprising medication errors are associated with impaired cognitive and physical function tests in the VALFORTA trialDrugs & aging","recId":"327644281","physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"display":"Pazan, Farhad","family":"Pazan","given":"Farhad","role":"aut"},{"display":"Burkhardt, Heinrich","given":"Heinrich","role":"aut","family":"Burkhardt"},{"family":"Weiß","role":"aut","given":"Christel","display":"Weiß, Christel"},{"role":"aut","given":"Martin","family":"Wehling","display":"Wehling, Martin"}],"id":{"eki":["1676783938"],"doi":["10.1007/s40266-018-0626-3"]},"name":{"displayForm":["Farhad Pazan, Heinrich Burkhardt, Helmut Frohnhofen, Christel Weiss, Christina Throm, Alexandra Kuhn-Thiel, Martin Wehling"]}} | ||
| SRT | |a PAZANFARHAHIGHERFITF2019 | ||