Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany: a multicenter, noninterventional study
This study assessed adherence to prolonged-release tacrolimus (PR-T)-based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received PR-T for ≥1 month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3), and 18...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
|
| In: |
Clinical transplantation
Year: 2017, Jahrgang: 32, Heft: 1 |
| ISSN: | 1399-0012 |
| DOI: | 10.1111/ctr.13142 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/ctr.13142 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13142 
|
| Verfasserangaben: | Lukas J. Lehner, Petra Reinke, Jan H. Hörstrup, Thomas Rath, Barbara Suwelack, Bernhard K. Krämer, Klemens Budde, Bernhard Banas |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1676950524 | ||
| 003 | DE-627 | ||
| 005 | 20230428155108.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190913r20182017xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/ctr.13142 |2 doi | |
| 035 | |a (DE-627)1676950524 | ||
| 035 | |a (DE-599)KXP1676950524 | ||
| 035 | |a (OCoLC)1341243317 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lehner, Lukas Johannes |e VerfasserIn |0 (DE-588)1188423355 |0 (DE-627)1667358057 |4 aut | |
| 245 | 1 | 0 | |a Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany |b a multicenter, noninterventional study |c Lukas J. Lehner, Petra Reinke, Jan H. Hörstrup, Thomas Rath, Barbara Suwelack, Bernhard K. Krämer, Klemens Budde, Bernhard Banas |
| 264 | 1 | |c 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.09.2019 | ||
| 500 | |a First published: 20 October 2017 | ||
| 520 | |a This study assessed adherence to prolonged-release tacrolimus (PR-T)-based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received PR-T for ≥1 month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3), and 18 (V4) months. Composite primary endpoint: nonadherence at V4, defined as self-reported nonadherence on the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS©), investigator-rated nonadherence, and/or V4 tacrolimus trough level outside a predefined range. Secondary endpoints: individual BAASIS items, incidence of rejection, kidney function, and safety. Overall, 153 adult kidney recipients (mean [standard deviation] time post-transplant 5.8 [4.6] years) were included. Nonadherence was high at V4 (67.7% [95% confidence interval 58.9%, 75.6%]). Medication-taking adherence was 86.9% and 91.3% at V1 and V4, respectively; adherence to timing of medication intake was 58.2% and 58.3%, with little evidence of missed doses/drug holidays. Investigators rated adherence “good” in 85.6% of patients (V4). Two (1.3%) patients had acute rejection episodes. Kidney function remained stable (mean creatinine clearance, V1: 62.1 mL/min; V4: 65.3 mL/min). Investigators rated effectiveness of PR-T as “very good”/“good” in 91.5% of patients. Most patients (94.7%) found PR-T dosing more convenient than immediate-release tacrolimus. PR-T was well tolerated with high medication persistence. | ||
| 534 | |c 2017 | ||
| 650 | 4 | |a immunosuppression | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a medication adherence | |
| 650 | 4 | |a tacrolimus | |
| 700 | 1 | |a Krämer, Bernhard |d 1957- |e VerfasserIn |0 (DE-588)14017589X |0 (DE-627)70358927X |0 (DE-576)314926852 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical transplantation |d Oxford [u.] : Wiley-Blackwell, 1999 |g 32(2018,1) Artikel-Nummer e13142, 9 Seiten |h Online-Ressource |w (DE-627)320439925 |w (DE-600)2004801-4 |w (DE-576)091142652 |x 1399-0012 |7 nnas |a Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany a multicenter, noninterventional study |
| 773 | 1 | 8 | |g volume:32 |g year:2018 |g number:1 |g extent:9 |a Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany a multicenter, noninterventional study |
| 856 | 4 | 0 | |u https://doi.org/10.1111/ctr.13142 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13142 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190913 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 14017589X |a Krämer, Bernhard |m 14017589X:Krämer, Bernhard |d 60000 |d 61400 |e 60000PK14017589X |e 61400PK14017589X |k 0/60000/ |k 1/60000/61400/ |p 6 | ||
| 999 | |a KXP-PPN1676950524 |e 3515804072 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"320439925","pubHistory":["Nachgewiesen 13.1999 -"],"id":{"issn":["1399-0012"],"eki":["320439925"],"zdb":["2004801-4"],"doi":["10.1111/(ISSN)1399-0012"]},"disp":"Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany a multicenter, noninterventional studyClinical transplantation","part":{"volume":"32","extent":"9","text":"32(2018,1) Artikel-Nummer e13142, 9 Seiten","year":"2018","issue":"1"},"title":[{"title_sort":"Clinical transplantation","title":"Clinical transplantation"}],"note":["Gesehen am 13.01.04"],"origin":[{"dateIssuedDisp":"1999-","publisherPlace":"Oxford [u.] ; Copenhagen ; Oxford ; Oxford [u.a.]","publisher":"Wiley-Blackwell ; Munksgaard International Publ. ; Blackwell Munksgaard ; Blackwell","dateIssuedKey":"1999"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"]}],"id":{"doi":["10.1111/ctr.13142"],"eki":["1676950524"]},"name":{"displayForm":["Lukas J. Lehner, Petra Reinke, Jan H. Hörstrup, Thomas Rath, Barbara Suwelack, Bernhard K. Krämer, Klemens Budde, Bernhard Banas"]},"physDesc":[{"extent":"9 S."}],"recId":"1676950524","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 13.09.2019","First published: 20 October 2017"],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"2018"}],"title":[{"title":"Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany","title_sort":"Evaluation of adherence and tolerability of prolonged-release tacrolimus (Advagraf™) in kidney transplant patients in Germany","subtitle":"a multicenter, noninterventional study"}],"language":["eng"],"person":[{"family":"Lehner","display":"Lehner, Lukas Johannes","given":"Lukas Johannes","role":"aut"},{"given":"Bernhard","role":"aut","family":"Krämer","display":"Krämer, Bernhard"}]} | ||
| SRT | |a LEHNERLUKAEVALUATION2018 | ||