A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice
Aberrant synaptic function is thought to underlie social deficits in neurodevelopmental disorders such as autism and schizophrenia. Although microRNAs have been shown to regulate synapse development and plasticity, their potential involvement in the control of social behaviour in mammals remains une...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
|
| In: |
EMBO reports
Year: 2019, Volume: 20, Issue: 2, Pages: e46429 |
| ISSN: | 1469-3178 |
| DOI: | 10.15252/embr.201846429 |
| Online Access: | Verlag, Volltext: https://doi.org/10.15252/embr.201846429 Verlag, Volltext: https://www.embopress.org/doi/full/10.15252/embr.201846429 
|
| Author Notes: | Martin Lackinger, A. Özge Sungur, Reetu Daswani, Michael Soutschek, Silvia Bicker, Lea Stemmler, Tatjana Wüst, Roberto Fiore, Christoph Dieterich, Rainer K.W. Schwarting, Markus Wöhr, Gerhard Schratt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1677152451 | ||
| 003 | DE-627 | ||
| 005 | 20220816225651.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190917s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embr.201846429 |2 doi | |
| 035 | |a (DE-627)1677152451 | ||
| 035 | |a (DE-599)KXP1677152451 | ||
| 035 | |a (OCoLC)1341243718 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lackinger, Martin |e VerfasserIn |0 (DE-588)1194963528 |0 (DE-627)1677153156 |4 aut | |
| 245 | 1 | 2 | |a A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice |c Martin Lackinger, A. Özge Sungur, Reetu Daswani, Michael Soutschek, Silvia Bicker, Lea Stemmler, Tatjana Wüst, Roberto Fiore, Christoph Dieterich, Rainer K.W. Schwarting, Markus Wöhr, Gerhard Schratt |
| 264 | 1 | |c 2019 | |
| 300 | |a ? | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.09.2019 | ||
| 520 | |a Aberrant synaptic function is thought to underlie social deficits in neurodevelopmental disorders such as autism and schizophrenia. Although microRNAs have been shown to regulate synapse development and plasticity, their potential involvement in the control of social behaviour in mammals remains unexplored. Here, we show that deletion of the placental mammal-specific miR379-410 cluster in mice leads to hypersocial behaviour, which is accompanied by increased excitatory synaptic transmission, and exaggerated expression of ionotropic glutamate receptor complexes in the hippocampus. Bioinformatic analyses further allowed us to identify five ?hub? microRNAs whose deletion accounts largely for the upregulation of excitatory synaptic genes observed, including Cnih2, Dlgap3, Prr7 and Src. Thus, the miR379-410 cluster acts a natural brake for sociability, and interfering with specific members of this cluster could represent a therapeutic strategy for the treatment of social deficits in neurodevelopmental disorders. | ||
| 650 | 4 | |a autism | |
| 650 | 4 | |a glutamate receptor | |
| 650 | 4 | |a hippocampus | |
| 650 | 4 | |a microRNA | |
| 650 | 4 | |a sociability | |
| 700 | 1 | |a Sungur, A. Özge |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dieterich, Christoph |d 1975- |e VerfasserIn |0 (DE-588)130054844 |0 (DE-627)494359269 |0 (DE-576)297972448 |4 aut | |
| 700 | 1 | |a Schwarting, Rainer |d 1955- |e VerfasserIn |0 (DE-588)1209416115 |0 (DE-627)1696990696 |4 aut | |
| 700 | 1 | |a Wöhr, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schratt, Gerhard |d 1972- |e VerfasserIn |0 (DE-588)129269344 |0 (DE-627)391873490 |0 (DE-576)184974690 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO reports |d [London] : Nature Publishing Group UK, 2000 |g 20(2019), 2, Seite e46429 |h Online-Ressource |w (DE-627)320645622 |w (DE-600)2025376-X |w (DE-576)095092153 |x 1469-3178 |7 nnas |
| 773 | 1 | 8 | |g volume:20 |g year:2019 |g number:2 |g pages:e46429 |g extent:? |a A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice |
| 856 | 4 | 0 | |u https://doi.org/10.15252/embr.201846429 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.embopress.org/doi/full/10.15252/embr.201846429 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190917 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 130054844 |a Dieterich, Christoph |m 130054844:Dieterich, Christoph |d 910000 |d 910100 |e 910000PD130054844 |e 910100PD130054844 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 999 | |a KXP-PPN1677152451 |e 3516249773 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1677152451"],"doi":["10.15252/embr.201846429"]},"recId":"1677152451","origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"relHost":[{"recId":"320645622","type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"display":"European Molecular Biology Organization","role":"aut"}],"pubHistory":["1.2000 -"],"disp":"European Molecular Biology OrganizationEMBO reports","part":{"issue":"2","extent":"?","year":"2019","text":"20(2019), 2, Seite e46429","volume":"20","pages":"e46429"},"id":{"doi":["10.1002/(ISSN)1469-3178"],"issn":["1469-3178"],"eki":["320645622"],"zdb":["2025376-X"]},"origin":[{"publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedDisp":"[2000]-","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publishing Group ; Wiley"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title":"EMBO reports","title_sort":"EMBO reports"}],"name":{"displayForm":["European Molecular Biology Organization"]},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.03.25"]}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Martin","role":"aut","family":"Lackinger","display":"Lackinger, Martin"},{"display":"Sungur, A. Özge","family":"Sungur","role":"aut","given":"A. Özge"},{"role":"aut","display":"Dieterich, Christoph","family":"Dieterich","given":"Christoph"},{"given":"Rainer","display":"Schwarting, Rainer","family":"Schwarting","role":"aut"},{"given":"Markus","family":"Wöhr","display":"Wöhr, Markus","role":"aut"},{"display":"Schratt, Gerhard","family":"Schratt","role":"aut","given":"Gerhard"}],"name":{"displayForm":["Martin Lackinger, A. Özge Sungur, Reetu Daswani, Michael Soutschek, Silvia Bicker, Lea Stemmler, Tatjana Wüst, Roberto Fiore, Christoph Dieterich, Rainer K.W. Schwarting, Markus Wöhr, Gerhard Schratt"]},"note":["Gesehen am 17.09.2019"],"physDesc":[{"extent":"? S."}],"language":["eng"],"title":[{"title_sort":"placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice","title":"A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice"}]} | ||
| SRT | |a LACKINGERMPLACENTALM2019 | ||