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Current status and trends in the diagnostics of AML and MDS

Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and risk stratification systems, a...

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Hauptverfasser: Shumilov, Evgenii (VerfasserIn) , Flach, Johanna (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018
In: Blood reviews
Year: 2018, Jahrgang: 32, Heft: 6, Pages: 508-519
ISSN:1532-1681
DOI:10.1016/j.blre.2018.04.008
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.blre.2018.04.008
Volltext
Verfasserangaben:Evgenii Shumilov, Johanna Flach, Alexander Kohlmann, Yara Banz, Nicolas Bonadies, Martin Fiedler, Thomas Pabst, Ulrike Bacher

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520 |a Diagnostics of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have recently been experiencing extensive modifications regarding the incorporation of next-generation sequencing (NGS) strategies into established diagnostic algorithms, classification and risk stratification systems, and minimal residual disease (MRD) detection. Considering the increasing arsenal of targeted therapies (e.g. FLT3 or IDH1/IDH2 inhibitors) for AML, timely and comprehensive molecular mutation screening has arrived in daily practice. Next-generation flow strategies allow for immunophenotypic minimal residual disease (MRD) monitoring with very high sensitivity. At the same time, standard diagnostic tools such as cytomorphology or conventional cytogenetics remain cornerstones for the diagnostic workup of myeloid malignancies. Herein, we summarize the most recent advances and new trends for the diagnostics of AML and MDS, discuss the difficulties, which accompany the integration of these new methods and their results into daily routine, and aim to define the role hemato-oncologists may play in this new diagnostic era. 
650 4 |a Acute myeloid leukemia (AML) 
650 4 |a Genetic Testing 
650 4 |a Genomics 
650 4 |a Humans 
650 4 |a Interpretation of hematological results 
650 4 |a Leukemia, Myeloid, Acute 
650 4 |a Molecular Diagnostic Techniques 
650 4 |a Molecular Targeted Therapy 
650 4 |a Myelodysplastic syndrome (MDS) 
650 4 |a Myelodysplastic Syndromes 
650 4 |a Neoplasm, Residual 
650 4 |a New diagnostic era 
650 4 |a Next-generation sequencing (NGS) 
650 4 |a Versatility of current laboratory approaches 
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