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Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new target for cancer...

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Main Authors: Behan, Fiona M. (Author) , Iorio, Francesco (Author) , Picco, Gabriele (Author) , Gonçalves, Emanuel (Author) , Beaver, Charlotte M. (Author) , Migliardi, Giorgia (Author) , Santos, Rita (Author) , Rao, Yanhua (Author) , Sassi, Francesco (Author) , Pinnelli, Marika (Author) , Ansari, Rizwan (Author) , Harper, Sarah (Author) , Jackson, David Adam (Author) , McRae, Rebecca (Author) , Pooley, Rachel (Author) , Wilkinson, Piers (Author) , Meer, Dieudonne van der (Author) , Dow, David (Author) , Buser-Doepner, Carolyn (Author) , Bertotti, Andrea (Author) , Trusolino, Livio (Author) , Stronach, Euan A. (Author) , Sáez Rodríguez, Julio (Author) , Yusa, Kosuke (Author) , Garnett, Mathew J. (Author)
Format: Article (Journal)
Language:English
Published: 10 April 2019
In: Nature
Year: 2019, Volume: 568, Issue: 7753, Pages: 511-516
ISSN:1476-4687
DOI:10.1038/s41586-019-1103-9
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41586-019-1103-9
Verlag, Volltext: https://www.nature.com/articles/s41586-019-1103-9
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Author Notes:Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Gonçalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari, Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne van der Meer, David Dow, Carolyn Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa & Mathew J. Garnett

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