Cover Image

At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1

Objective: Hyperthyroidism is associated with increased metabolism (“thyroid thermogenesis”) and elevated body temperature, often referred toas hyperthermia. Uncoupling protein-1 (UCP1) is the protein responsible for nonshivering thermogenesis in brown adipose tissue. We hereexamine whether UCP1 is...

Full description

Saved in:
Bibliographic Details
Main Author: Dittner, Claudia (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Molecular metabolism
Year: 2019, Volume: 19, Pages: 20-34
ISSN:2212-8778
DOI:10.1016/j.molmet.2019.05.005
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.molmet.2019.05.005
Get full text
Author Notes:Claudia Dittner, Erik Linds, Barbara Cannon, Jan Nedergaard

MARC

LEADER 00000caa a2200000 c 4500
001 1677759712
003 DE-627
005 20220816232532.0
007 cr uuu---uuuuu
008 190925s2019 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.molmet.2019.05.005  |2 doi 
035 |a (DE-627)1677759712 
035 |a (DE-599)KXP1677759712 
035 |a (OCoLC)1341244360 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Dittner, Claudia  |e VerfasserIn  |0 (DE-588)1082763217  |0 (DE-627)847779165  |0 (DE-576)455554617  |4 aut 
245 1 0 |a At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1  |c Claudia Dittner, Erik Linds, Barbara Cannon, Jan Nedergaard 
264 1 |c 2019 
300 |a 15 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.09.2019 
500 |a Available online 26 May 2019 
520 |a Objective: Hyperthyroidism is associated with increased metabolism (“thyroid thermogenesis”) and elevated body temperature, often referred toas hyperthermia. Uncoupling protein-1 (UCP1) is the protein responsible for nonshivering thermogenesis in brown adipose tissue. We hereexamine whether UCP1 is essential for thyroid thermogenesis.Methods:We investigated the significance of UCP1 for thyroid thermogenesis by using UCP1-ablated (UCP1 KO) mice. To avoid confoundingfactors from cold-induced thermogenesis and to approach human conditions, the experiments were conducted at thermoneutrality, and to resemble conditions of endogenous release, thyroid hormone (thyroxine, T4) was injected peripherally. Results: Both short-term and chronic thyroxine treatment led to a marked increase in metabolism that was largely UCP1-independent. Chronic thyroxine treatment led to a 1–2 °C increase in body temperature. This increase was also UCP1-independent and was maintained even at lower ambient temperatures. Thus, it was pyrexia, i.e. a defended increase in body temperature, not hyperthermia. In wildtype mice, chronic thyroxine treatment induced a large relative increase in the total amounts of UCP1 in the brown adipose tissue (practically no UCP1 in brite/beige adipose tissue), corresponding to an enhanced thermogenic response to norepinephrine injection. The increased UCP1 amount had minimal effects on thyroxine-induced thermogenesis and pyrexia. Conclusions These results establish that thyroid thermogenesis is a UCP1-independent process. The fact that the increased metabolism coincides with elevated body temperature and thus with accelerated kinetics accentuates the unsolved issue of the molecular background for thyroid thermogenesis. 
773 0 8 |i Enthalten in  |t Molecular metabolism  |d Oxford [u.a.] : Elsevier, 2012  |g 19(2019), Seite 20-34  |h Online-Ressource  |w (DE-627)739898752  |w (DE-600)2708735-9  |w (DE-576)380470314  |x 2212-8778  |7 nnas  |a At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1 
773 1 8 |g volume:19  |g year:2019  |g pages:20-34  |g extent:15  |a At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1 
856 4 0 |u https://doi.org/10.1016/j.molmet.2019.05.005  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20190925 
993 |a Article 
994 |a 2019 
998 |g 1082763217  |a Dittner, Claudia  |m 1082763217:Dittner, Claudia  |d 60000  |d 63200  |e 60000PD1082763217  |e 63200PD1082763217  |k 0/60000/  |k 1/60000/63200/  |p 1  |x j 
999 |a KXP-PPN1677759712  |e 3518039393 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"family":"Dittner","given":"Claudia","display":"Dittner, Claudia","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1","title_sort":"At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1"}],"language":["eng"],"recId":"1677759712","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 25.09.2019","Available online 26 May 2019"],"name":{"displayForm":["Claudia Dittner, Erik Linds, Barbara Cannon, Jan Nedergaard"]},"id":{"doi":["10.1016/j.molmet.2019.05.005"],"eki":["1677759712"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2212-8778"],"eki":["739898752"],"zdb":["2708735-9"]},"origin":[{"dateIssuedDisp":"2012-","publisher":"Elsevier","dateIssuedKey":"2012","publisherPlace":"Oxford [u.a.]"}],"part":{"volume":"19","text":"19(2019), Seite 20-34","extent":"15","year":"2019","pages":"20-34"},"pubHistory":["1.2012 -"],"recId":"739898752","language":["eng"],"note":["Gesehen am 25.06.20"],"disp":"At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1Molecular metabolism","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Molecular metabolism","subtitle":"official journal of the German Center for Diabetes Research (DZD)","title_sort":"Molecular metabolism"}]}],"physDesc":[{"extent":"15 S."}]} 
SRT |a DITTNERCLAATTHERMONE2019 

Similar Items