Can we predict cognitive decline after initial diagnosis of multiple sclerosis?: results from the German national early MS cohort (KKNMS)
BackgroundCognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI and progression after initial diagnosis.MethodsNeuropsychological screening data from baseline an...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
|
| In: |
Journal of neurology
Year: 2018, Volume: 266, Issue: 2, Pages: 386-397 |
| ISSN: | 1432-1459 |
| DOI: | 10.1007/s00415-018-9142-y |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/s00415-018-9142-y Verlag: https://link.springer.com/article/10.1007%2Fs00415-018-9142-y 
|
| Author Notes: | Andreas Johnen, Paul-Christian Bürkner, Nils C. Landmeyer, Björn Ambrosius, Pasquale Calabrese, Jeremias Motte, Nicole Hessler, Gisela Antony, Inke R. König, Luisa Klotz, Muna-Miriam Hoshi, Lilian Aly, Sergiu Groppa, Felix Luessi, Friedemann Paul, Björn Tackenberg, Florian Then Bergh, Tania Kümpfel, Hayrettin Tumani, Martin Stangel, Frank Weber, Antonios Bayas, Brigitte Wildemann, Christoph Heesen, Uwe K. Zettl, Frauke Zipp, Bernhard Hemmer, Sven G. Meuth, Ralf Gold, Heinz Wiendl, Anke Salmen+, on behalf of German Competence Network Multiple Sclerosis (KKNMS) |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1677907525 | ||
| 003 | DE-627 | ||
| 005 | 20220816233102.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190930r20192018xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00415-018-9142-y |2 doi | |
| 035 | |a (DE-627)1677907525 | ||
| 035 | |a (DE-599)KXP1677907525 | ||
| 035 | |a (OCoLC)1341244583 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Johnen, Andreas |d 1984- |e VerfasserIn |0 (DE-588)143637479 |0 (DE-627)704553848 |0 (DE-576)33810755X |4 aut | |
| 245 | 1 | 0 | |a Can we predict cognitive decline after initial diagnosis of multiple sclerosis? |b results from the German national early MS cohort (KKNMS) |c Andreas Johnen, Paul-Christian Bürkner, Nils C. Landmeyer, Björn Ambrosius, Pasquale Calabrese, Jeremias Motte, Nicole Hessler, Gisela Antony, Inke R. König, Luisa Klotz, Muna-Miriam Hoshi, Lilian Aly, Sergiu Groppa, Felix Luessi, Friedemann Paul, Björn Tackenberg, Florian Then Bergh, Tania Kümpfel, Hayrettin Tumani, Martin Stangel, Frank Weber, Antonios Bayas, Brigitte Wildemann, Christoph Heesen, Uwe K. Zettl, Frauke Zipp, Bernhard Hemmer, Sven G. Meuth, Ralf Gold, Heinz Wiendl, Anke Salmen+, on behalf of German Competence Network Multiple Sclerosis (KKNMS) |
| 264 | 1 | |c 2019 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 4 December 2018 | ||
| 500 | |a Gesehen am 20.11.2019 | ||
| 520 | |a BackgroundCognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI and progression after initial diagnosis.MethodsNeuropsychological screening data from baseline and 1-year follow-up of a prospective multicenter cohort study (NationMS) involving 1123 patients with newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical and conventional MRI markers at baseline were predictive for CI and longitudinal cognitive changes.ResultsAt baseline, 22% of patients had CI (impairment in ≥2 cognitive domains) with highest frequencies and severity in processing speed and executive functions. Demographics (fewer years of academic education, higher age, male sex), clinical (EDSS, depressive symptoms) but no conventional MRI characteristics were linked to baseline CI. At follow-up, only 14% of patients showed CI suggesting effects of retesting. Neither baseline characteristics nor initiation of treatment between baseline and follow-up was able to predict cognitive changes within the follow-up period of 1 year.ConclusionsIdentification of risk factors for short-term cognitive change in newly diagnosed MS or CIS is insufficient using only demographic, clinical and conventional MRI data. Change-sensitive, re-test reliable cognitive tests and more sophisticated predictors need to be employed in future clinical trials and cohort studies of early-stage MS to improve prediction. | ||
| 534 | |c 2018 | ||
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Cohort study | |
| 650 | 4 | |a Longitudinal | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Neuropsychology | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurology |d [Darmstadt] : Steinkopff, 1974 |g 266(2019), 2, Seite 386-397 |h Online-Ressource |w (DE-627)242065155 |w (DE-600)1421299-7 |w (DE-576)065026500 |x 1432-1459 |7 nnas |a Can we predict cognitive decline after initial diagnosis of multiple sclerosis? results from the German national early MS cohort (KKNMS) |
| 773 | 1 | 8 | |g volume:266 |g year:2019 |g number:2 |g pages:386-397 |g extent:12 |a Can we predict cognitive decline after initial diagnosis of multiple sclerosis? results from the German national early MS cohort (KKNMS) |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00415-018-9142-y |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007%2Fs00415-018-9142-y |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20190930 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |e 910000PW110203844 |e 911100PW110203844 |k 0/910000/ |k 1/910000/911100/ |p 23 | ||
| 999 | |a KXP-PPN1677907525 |e 3518998897 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"origin":[{"publisher":"Steinkopff ; Springer ; Steinkopff [u.a.] ; Springer-Medizin-Verl.","dateIssuedDisp":"1974-","publisherPlace":"[Darmstadt] ; Berlin ; Heidelberg [u.a.] ; Darmstadt ; Heidelberg","dateIssuedKey":"1974"}],"pubHistory":["Volume 207, issue 1 (March 1974)-"],"language":["eng","ger"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal of neurology","title":"Journal of neurology"}],"note":["Gesehen am 14.03.25","Ungezählte Beil.: Supplement"],"part":{"pages":"386-397","year":"2019","volume":"266","text":"266(2019), 2, Seite 386-397","extent":"12","issue":"2"},"recId":"242065155","disp":"Can we predict cognitive decline after initial diagnosis of multiple sclerosis? results from the German national early MS cohort (KKNMS)Journal of neurology","id":{"zdb":["1421299-7"],"eki":["242065155"],"issn":["1432-1459"]},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"person":[{"given":"Andreas","family":"Johnen","display":"Johnen, Andreas","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Wildemann","given":"Brigitte","display":"Wildemann, Brigitte","roleDisplay":"VerfasserIn","role":"aut"}],"name":{"displayForm":["Andreas Johnen, Paul-Christian Bürkner, Nils C. Landmeyer, Björn Ambrosius, Pasquale Calabrese, Jeremias Motte, Nicole Hessler, Gisela Antony, Inke R. König, Luisa Klotz, Muna-Miriam Hoshi, Lilian Aly, Sergiu Groppa, Felix Luessi, Friedemann Paul, Björn Tackenberg, Florian Then Bergh, Tania Kümpfel, Hayrettin Tumani, Martin Stangel, Frank Weber, Antonios Bayas, Brigitte Wildemann, Christoph Heesen, Uwe K. Zettl, Frauke Zipp, Bernhard Hemmer, Sven G. Meuth, Ralf Gold, Heinz Wiendl, Anke Salmen+, on behalf of German Competence Network Multiple Sclerosis (KKNMS)"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1677907525","title":[{"title_sort":"Can we predict cognitive decline after initial diagnosis of multiple sclerosis?","subtitle":"results from the German national early MS cohort (KKNMS)","title":"Can we predict cognitive decline after initial diagnosis of multiple sclerosis?"}],"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"language":["eng"],"id":{"eki":["1677907525"],"doi":["10.1007/s00415-018-9142-y"]},"note":["Published online: 4 December 2018","Gesehen am 20.11.2019"],"physDesc":[{"extent":"12 S."}]} | ||
| SRT | |a JOHNENANDRCANWEPREDI2019 | ||