Transplant outcomes for secondary acute myeloid leukemia: acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation Study
Secondary acute myeloid leukemia (sAML) has been associated with inferior outcomes compared with de novo AML. Little is known about patient risk factors and outcomes in sAML after allogeneic hematopoietic stem cell transplantation (HCT); thus, this large systemic analysis of the European Society for...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 April 2018
|
| In: |
Biology of blood and marrow transplantation
Year: 2018, Jahrgang: 24, Heft: 7, Pages: 1406-1414 |
| ISSN: | 1523-6536 |
| DOI: | 10.1016/j.bbmt.2018.04.008 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.bbmt.2018.04.008 Verlag: http://www.sciencedirect.com/science/article/pii/S1083879118301897 
|
| Verfasserangaben: | Salyka Sengsayadeth, Myriam Labopin, Ariane Boumendil, Jürgen Finke, Arnold Ganser, Matthias Stelljes, Gerhard Ehninger, Dietrich Beelen, Dietger Niederwieser, Didier Blaise, Peter Dreger, Ghulam Mufti, Patrice Chevallier, Audrey Mailhol, Katie S. Gatwood, Norbert Gorin, Jordi Esteve, Fabio Ciceri, Frederic Baron, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Bipin N. Savani, Arnon Nagler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1677919256 | ||
| 003 | DE-627 | ||
| 005 | 20230428021907.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190930s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bbmt.2018.04.008 |2 doi | |
| 035 | |a (DE-627)1677919256 | ||
| 035 | |a (DE-599)KXP1677919256 | ||
| 035 | |a (OCoLC)1341244658 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sengsayadeth, Salyka |e VerfasserIn |0 (DE-588)1196042128 |0 (DE-627)1677918500 |4 aut | |
| 245 | 1 | 0 | |a Transplant outcomes for secondary acute myeloid leukemia |b acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation Study |c Salyka Sengsayadeth, Myriam Labopin, Ariane Boumendil, Jürgen Finke, Arnold Ganser, Matthias Stelljes, Gerhard Ehninger, Dietrich Beelen, Dietger Niederwieser, Didier Blaise, Peter Dreger, Ghulam Mufti, Patrice Chevallier, Audrey Mailhol, Katie S. Gatwood, Norbert Gorin, Jordi Esteve, Fabio Ciceri, Frederic Baron, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Bipin N. Savani, Arnon Nagler |
| 264 | 1 | |c 17 April 2018 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.09.2019 | ||
| 520 | |a Secondary acute myeloid leukemia (sAML) has been associated with inferior outcomes compared with de novo AML. Little is known about patient risk factors and outcomes in sAML after allogeneic hematopoietic stem cell transplantation (HCT); thus, this large systemic analysis of the European Society for Blood and Bone Marrow Transplantation registry was performed. This study included 4997 patients with sAML who received HCT from 2000 to 2016. In univariate analysis the 2-year cumulative incidence of chronic graft-versus-host disease (GVHD), relapse, and nonrelapse mortality (NRM) were 33.5% (95% confidence interval [CI], 32% to 34.9%), 33.7% (95% CI, 32.3% to 35.1%), and 27.5% (95% CI, 26.1% to 28.7%), respectively. Overall survival (OS), leukemia-free survival (LFS), and GVHD-free, relapse-free survival (GRFS) at 2 years were 44.5% (95% CI, 43% to 46%), 38.8% (95% CI, 37.4% to 40.3%), and 27.2% (95% CI, 25.9% to 28.6%), respectively. In multivariate analysis, patients receiving myeloablative regimens had decreased relapse (hazard ratio, .859; 95% CI, .761 to .97; P = .01), higher NRM (hazard ratio, 1.175; 95% CI, 1.03 to 1.341; P = .02), and no differences in OS, LFS, and GRFS compared with patients receiving reduced-intensity conditioning regimens. Active disease, adverse cytogenetics, older age, Karnofsky performance status (≤80%), ex vivo T cell depletion, other malignant hematologic diseases, and patient cytomegalovirus seropositivity were associated with inferior OS and LFS. These variables should be considered in patients with sAML in need of HCT, and further study regarding the impact of conditioning regimens on relapse is needed. | ||
| 650 | 4 | |a Acute myeloid leukemia | |
| 650 | 4 | |a Allogeneic stem cell transplantation | |
| 650 | 4 | |a Antileukemic effect | |
| 650 | 4 | |a Conditioning | |
| 650 | 4 | |a Secondary | |
| 650 | 4 | |a Toxicity | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biology of blood and marrow transplantation |d [Erscheinungsort nicht ermittelbar] : Elsevier Health Sciences, 1998 |g 24(2018), 7, Seite 1406-1414 |h Online-Ressource |w (DE-627)334374782 |w (DE-600)2057605-5 |w (DE-576)118352229 |x 1523-6536 |7 nnas |a Transplant outcomes for secondary acute myeloid leukemia acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation Study |
| 773 | 1 | 8 | |g volume:24 |g year:2018 |g number:7 |g pages:1406-1414 |g extent:9 |a Transplant outcomes for secondary acute myeloid leukemia acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation Study |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bbmt.2018.04.008 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1083879118301897 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20190930 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 999 | |a KXP-PPN1677919256 |e 3519026147 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Transplant outcomes for secondary acute myeloid leukemia","title":"Transplant outcomes for secondary acute myeloid leukemia","subtitle":"acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation Study"}],"name":{"displayForm":["Salyka Sengsayadeth, Myriam Labopin, Ariane Boumendil, Jürgen Finke, Arnold Ganser, Matthias Stelljes, Gerhard Ehninger, Dietrich Beelen, Dietger Niederwieser, Didier Blaise, Peter Dreger, Ghulam Mufti, Patrice Chevallier, Audrey Mailhol, Katie S. Gatwood, Norbert Gorin, Jordi Esteve, Fabio Ciceri, Frederic Baron, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Bipin N. Savani, Arnon Nagler"]},"person":[{"family":"Sengsayadeth","role":"aut","given":"Salyka","display":"Sengsayadeth, Salyka"},{"display":"Dreger, Peter","given":"Peter","role":"aut","family":"Dreger"}],"recId":"1677919256","origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"17 April 2018"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"pubHistory":["Volume 4, issue 1 (June 1998)-Volume 26, issue 12 (December 2020)"],"title":[{"title_sort":"Biology of blood and marrow transplantation","title":"Biology of blood and marrow transplantation","subtitle":"BBMT ; the official journal of the American Society for Blood and Marrow Transplantation"}],"language":["eng"],"part":{"issue":"7","extent":"9","pages":"1406-1414","volume":"24","year":"2018","text":"24(2018), 7, Seite 1406-1414"},"titleAlt":[{"title":"BBMT"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"334374782","origin":[{"publisherPlace":"[Erscheinungsort nicht ermittelbar] ; Charlottesville, Va.","publisher":"Elsevier Health Sciences ; Carden Jennings","dateIssuedDisp":"[1998-2020]"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Transplant outcomes for secondary acute myeloid leukemia acute leukemia working party of the European Society for Blood and Bone Marrow Transplantation StudyBiology of blood and marrow transplantation","id":{"zdb":["2057605-5"],"issn":["1523-6536"],"eki":["334374782"]},"note":["Gesehen am 16.03.2021"]}],"note":["Gesehen am 30.09.2019"],"id":{"doi":["10.1016/j.bbmt.2018.04.008"],"eki":["1677919256"]},"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a SENGSAYADETRANSPLANT1720 | ||