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3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

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The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed for reference anatomies, simplified activity distributions, and a physiological BM distri...

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Bibliographic Details
Main Authors: Gosewisch, Astrid (Author) , Mairani, Andrea (Author)
Format: Article (Journal)
Language:English
Published: 14 August 2019
In: EJNMMI Research
Year: 2019, Volume: 9
ISSN:2191-219X
DOI:10.1186/s13550-019-0548-z
Online Access:Verlag, Volltext: https://doi.org/10.1186/s13550-019-0548-z
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Author Notes:Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning

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