3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT
The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed for reference anatomies, simplified activity distributions, and a physiological BM distri...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 August 2019
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| In: |
EJNMMI Research
Year: 2019, Volume: 9 |
| ISSN: | 2191-219X |
| DOI: | 10.1186/s13550-019-0548-z |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s13550-019-0548-z
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| Author Notes: | Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning |
| Summary: | The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed for reference anatomies, simplified activity distributions, and a physiological BM distribution. However, mCRPC patients may show a considerable bone lesion load, which leads to a heterogeneous and patient-specific activity accumulation close to BM-bearing sites. Furthermore, the patient-specific BM distribution might be significantly altered in the presence of bone lesions. The aim was to perform BM absorbed dose calculations through Monte Carlo (MC) simulations and to investigate the potential value of image-based BM localization. |
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| Item Description: | Gesehen am 30.09.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2191-219X |
| DOI: | 10.1186/s13550-019-0548-z |