Quantitative self-assembly prediction yields targeted nanomedicines

Molecular simulations reveal the self-assembly of small molecules into nanoparticle drug carriers. Targeting of colon and liver cancer cells by the nanoparticles via kinase inhibitors is employed in anti-tumour therapy in vivo.

Bibliographic Details

Main Authors:	Shamay, Yosi (Author) , Shah, Janki (Author) , Işık, Mehtap (Author) , Mizrachi, Aviram (Author) , Leibold, Josef (Author) , Tschaharganeh, Darjus-Felix (Author) , Roxbury, Daniel (Author) , Budhathoki-Uprety, Januka (Author) , Nawaly, Karla (Author) , Sugarman, James L. (Author) , Baut, Emily (Author) , Neiman, Michelle R. (Author) , Dacek, Megan (Author) , Ganesh, Kripa S. (Author) , Johnson, Darren C. (Author) , Sridharan, Ramya (Author) , Chu, Karen L. (Author) , Rajasekhar, Vinagolu K. (Author) , Lowe, Scott W. (Author) , Chodera, John D. (Author) , Heller, Daniel A. (Author)
Format:	Article (Journal)
Language:	English
Published:	05 February 2018
In:	Nature materials Year: 2018, Volume: 17, Issue: 4, Pages: 361-368
ISSN:	1476-4660
DOI:	10.1038/s41563-017-0007-z
Online Access:	Verlag, Volltext: https://doi.org/10.1038/s41563-017-0007-z Verlag: https://www.nature.com/articles/s41563-017-0007-z
Author Notes:	Yosi Shamay, Janki Shah, Mehtap Işık, Aviram Mizrachi, Josef Leibold, Darjus F. Tschaharganeh, Daniel Roxbury, Januka Budhathoki-Uprety, Karla Nawaly, James L. Sugarman, Emily Baut, Michelle R. Neiman, Megan Dacek, Kripa S. Ganesh, Darren C. Johnson, Ramya Sridharan, Karen L. Chu, Vinagolu K. Rajasekhar, Scott W. Lowe, John D. Chodera and Daniel A. Heller