Cover Image

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine incorporator proteins 3 (SERINC3) and 5 (SERINC5) were...

Full description

Saved in:
Bibliographic Details
Main Authors: Sousa-Pereira, Patrícia de (Author) , Pierini, Virginia (Author) , Fackler, Oliver Till (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Journal of general virology
Year: 2018, Volume: 100, Issue: 2, Pages: 278-288
ISSN:1465-2099
DOI:10.1099/jgv.0.001201
Online Access:Verlag, Volltext: https://doi.org/10.1099/jgv.0.001201
Verlag: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001201
Get full text
Author Notes:Patrícia de Sousa-Pereira, Joana Abrantes, Stefan Bauernfried, Virginia Pierini, Pedro José Esteves, Oliver T. Keppler, Massimo Pizzato, Veit Hornung, Oliver T. Fackler, Hanna-Mari Baldauf
Description
Summary:A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine incorporator proteins 3 (SERINC3) and 5 (SERINC5) were recently identified as restriction factors that reduce HIV-1 infectivity. Here, we compared the antiviral activity of SERINC3 and SERINC5 among mice, rats and rabbits, and their susceptibility to viral counteraction to their human counterparts. In the absence of viral antagonists, rodent and lagomorph SERINC3 and SERINC5 displayed anti-HIV activity in a similar range to human controls. Vesicular stomatitis virus G protein (VSV-G) pseudotyped virions were considerably less sensitive to restriction by all SERINC3/5 orthologs. Interestingly, HIV-1 Nef, murine leukemia virus (MLV) GlycoGag and equine infectious anemia virus (EIAV) S2 counteracted the antiviral activity of all SERINC3/5 orthologs with similar efficiency. Our results demonstrate that the antiviral activity of SERINC3/5 proteins is conserved in rodents and rabbits, and can be overcome by all three previously reported viral antagonists.,
Item Description:First published: 19 December 2018
Gesehen am 19.11.2019
Physical Description:Online Resource
ISSN:1465-2099
DOI:10.1099/jgv.0.001201

Similar Items