Peridural analgesia does not impact survival in patients after colon cancer resection: a retrospective propensity score-adjusted analysis
PurposeTo assess the putative impact of peridural analgesia on oncological outcome in patients undergoing resection of stages I-IV colon cancer.MethodsIn a single-center study, 876 patients undergoing resection for primary colon cancer (AJCC stages I-IV) between 2001 and 2014 were analyzed. Mean fol...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 June 2019
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| In: |
International journal of colorectal disease
Year: 2019, Jahrgang: 34, Heft: 7, Pages: 1283-1293 |
| ISSN: | 1432-1262 |
| DOI: | 10.1007/s00384-019-03315-0 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00384-019-03315-0
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| Verfasserangaben: | Elena F. Wurster, Frank Pianka, Rene Warschkow, Pia Antony, Thorsten Brenner, Markus A. Weigand, Bruno M. Schmied, Markus W. Büchler, Ignazio Tarantino, Alexis Ulrich |
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| 245 | 1 | 0 | |a Peridural analgesia does not impact survival in patients after colon cancer resection |b a retrospective propensity score-adjusted analysis |c Elena F. Wurster, Frank Pianka, Rene Warschkow, Pia Antony, Thorsten Brenner, Markus A. Weigand, Bruno M. Schmied, Markus W. Büchler, Ignazio Tarantino, Alexis Ulrich |
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| 520 | |a PurposeTo assess the putative impact of peridural analgesia on oncological outcome in patients undergoing resection of stages I-IV colon cancer.MethodsIn a single-center study, 876 patients undergoing resection for primary colon cancer (AJCC stages I-IV) between 2001 and 2014 were analyzed. Mean follow-up of the entire cohort was 4.2 ± 3.5 years. Patients who did and did not receive peridural analgesia were compared using Cox regression and propensity score analyses.ResultsOverall, 208 patients (23.7%) received peridural analgesia. Patients’ characteristics were biased with regard to the use of peridural analgesia (propensity score 0.296 ± 0.129 vs. 0.219 ± 0.108, p < 0.001). After propensity score matching, the use of peridural analgesia had no impact on overall (HR 0.81, 95% CI 0.59-1.11, p = 0.175), cancer-specific (HR 0.72, 95% CI 0.48-1.09, p = 0.111), and disease-free survival (HR 0.89, 95% CI 0.66-1.19, p = 0.430). The 5-year overall survival after propensity score matching was 60.9% (95% CI 54.8-67.7%) for patients treated with peridural analgesia compared with 54.1% (95% CI 49.5-59.1%) for patients not treated with peridural analgesia. Cancer-specific and disease-free survival showed similar non-significant results.ConclusionsPeridural analgesia in patients after colon cancer resection was not associated with a better oncological outcome after risk adjusting in multivariable Cox regression and propensity score analyses. Hence, oncological outcome should not serve as a reason for the use of peridural analgesia in patients with colon cancer. | ||
| 650 | 4 | |a Cancer-specific survival | |
| 650 | 4 | |a Colon cancer | |
| 650 | 4 | |a Overall survival | |
| 650 | 4 | |a Peridural analgesia | |
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