Elective node irradiation with integrated boost to the prostate using helical IMRT: clinical outcome of the prospective PLATIN-1 trial
Introduction: This prospective, non-randomized phase II trial aimed to investigate the role of additional irradiation of the pelvic nodes for patients with prostate cancer and a high risk for nodal metastases using helical intensity-modulated radiotherapy with daily image guidance (IMRT/IGRT). Metho...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 August 2019
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| In: |
Frontiers in oncology
Year: 2019, Jahrgang: 9 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2019.00751 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fonc.2019.00751 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2019.00751/full 
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| Verfasserangaben: | Stefan Alexander Koerber, Erik Winter, Sonja Katayama, Alla Slynko, Matthias Felix Haefner, Matthias Uhl, Florian Sterzing, Gregor Habl, Kai Schubert, Juergen Debus and Klaus Herfarth |
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| 245 | 1 | 0 | |a Elective node irradiation with integrated boost to the prostate using helical IMRT |b clinical outcome of the prospective PLATIN-1 trial |c Stefan Alexander Koerber, Erik Winter, Sonja Katayama, Alla Slynko, Matthias Felix Haefner, Matthias Uhl, Florian Sterzing, Gregor Habl, Kai Schubert, Juergen Debus and Klaus Herfarth |
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| 520 | |a Introduction: This prospective, non-randomized phase II trial aimed to investigate the role of additional irradiation of the pelvic nodes for patients with prostate cancer and a high risk for nodal metastases using helical intensity-modulated radiotherapy with daily image guidance (IMRT/IGRT). Methods and materials: Between 2009 and 2012, 40 men with treatment-naïve prostate cancer and a risk of lymph node involvement of more than 20% were enrolled in the PLATIN-1 trial. All patients received definitive, helical IMRT of the pelvic nodes (total dose of 51.0 Gy) with a simultaneous integrated boost (SIB) to the prostate (total dose of 76.5 Gy) in 34 fractions. Antihormonal therapy (AHT) was administered for a minimum of two months before radiotherapy continuing for at least 24 months. Results: After a median follow-up of 71 months (range: 5 - 95 months), pelvic irradiation was associated with a 5-year overall survival (OS) and biochemical progression-free survival (bPFS) of 94.3% and 83.6%, respectively. For our cohort, no grade 4 gastrointestinal (GI) and genitourinary (GU) toxicity was observed. Quality of life (QoL) assessed by EORTC QLQ-C30 questionnaire was comparable to EORTC reference values without significant changes. Conclusion: The current trial demonstrates that elective IMRT/IGRT of the pelvic nodes with SIB to the prostate for patients with a high-risk of lymphatic spread is safe and shows an excellent clinical outcome without compromising the quality of life. The PLATIN-1 trial delivers eminent baseline data for future studies using modern irradiation techniques. | ||
| 650 | 4 | |a Elective node irradiation | |
| 650 | 4 | |a IMRT (intensity modulated radiation therapy) | |
| 650 | 4 | |a Pelvic nodes | |
| 650 | 4 | |a prostate cancer | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a simultaneous integrated boost (SIB) | |
| 650 | 4 | |a Tomotherapy ® | |
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