Subjective evaluation of visual acuity is not reliable to detect disease activity in different exudative maculopathies
Background: Patients with exudative maculopathies (neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)) are faced with a high burden of examinations and treatments. This study was conceived to analyze the accuracy of a subjective evalua...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 June 2018
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| In: |
Graefe's archive for clinical and experimental ophthalmology
Year: 2018, Jahrgang: 256, Heft: 9, Pages: 1565-1571 |
| ISSN: | 1435-702X |
| DOI: | 10.1007/s00417-018-4021-x |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00417-018-4021-x
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| Verfasserangaben: | Marie-Christine Bruender, Nicola Benjamin, Hansjuergen Thomas Agostini, Andreas Stahl, Christoph Ehlken |
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| 245 | 1 | 0 | |a Subjective evaluation of visual acuity is not reliable to detect disease activity in different exudative maculopathies |c Marie-Christine Bruender, Nicola Benjamin, Hansjuergen Thomas Agostini, Andreas Stahl, Christoph Ehlken |
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| 520 | |a Background: Patients with exudative maculopathies (neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)) are faced with a high burden of examinations and treatments. This study was conceived to analyze the accuracy of a subjective evaluation of visual acuity (VA) and metamorphopsia to detect disease reactivation, compared to morphological signs of reactivation assessed by means of SD-OCT. Methods: Retrospective study of 888 patients treated for nAMD (n = 638), DME (84), BRVO (110), and CRVO (56) was conducted. Subjective evaluation of the patient at an examination (i.e., change of VA and/or metamorphopsia) was compared to clinical evaluation of disease activity as assessed by SD-OCT. Sensitivity and specificity, negative and positive predictive values (PPV/NPV) for detection of active disease were calculated. Factors associated with false-negative subjective evaluation were analyzed by regression analysis. Results: The sensitivity of the subjective evaluation to detect disease reactivation was < 0.50 in all exudative maculopathies. Sensitivity was increased to ≥ 0.60 by combining subjective worsening with loss of 1 line in the VA test in RVO, but not in DME and nAMD. The specificity was > 0.85 in all patients. PPV was > 0.85 in patients with RVO. Regression analysis did not reveal any factors that could reliably identify patient subgroups in which OCT could be omitted, though CRVO patients with a visual acuity of < 0.3 logMAR had an odds ratio of 0.20 for false-negative subjective evaluation (p = 0.009). Conclusion: The accuracy of subjective evaluation to discriminate disease activity in patients with different exudative maculopathies was low and cannot substitute for frequent SD-OCT exams. Routinely assessed clinical parameters such as age, visual acuity, or treatment experience were of no use to predict the validity of subjective evaluation of disease activity. Trial registration: This trial was registered at the DRKS (Deutsches Register Klinischer Studien, drks.de; No 00006851) prior to the inclusion of the first patient. | ||
| 650 | 4 | |a Diagnosis | |
| 650 | 4 | |a Diagnostic accuracy | |
| 650 | 4 | |a Macular edema | |
| 650 | 4 | |a Maculopathy | |
| 650 | 4 | |a Sensitivity | |
| 650 | 4 | |a Specificity | |
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