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A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling

Fibroblast growth factor 2 (FGF2) is a cell survival factor with crucial functions in tumor-induced angiogenesis. Here, we describe a novel time-resolved FGF2 signaling assay based upon live cell imaging of neuroblastoma cells. To validate this system, we tested 8960 small molecules for inhibition o...

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Main Authors: Ahmed, MennatAllah (Author) , Legrand, Cyril (Author) , Beretta, Carlo Antonio (Author) , Muschko, Alina (Author) , Wegehingel, Sabine (Author) , Müller, Hans-Michael (Author) , Nickel, Walter (Author)
Format: Article (Journal)
Language:English
Published: 7 June 2019
In: FEBS letters
Year: 2019, Volume: 593, Issue: 16, Pages: 2162-2176
ISSN:1873-3468
DOI:10.1002/1873-3468.13462
Online Access:Verlag, Volltext: https://doi.org/10.1002/1873-3468.13462
Verlag: https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13462
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Author Notes:Mennatallah Ahmed, Cyril Legrand, Ana Yagüe Relimpio, Carlo A. Beretta, Alina Muschko, Sabine Wegehingel, Hans-Michael Müller, Peter Sehr, David W. Will, Joe D. Lewis and Walter Nickel

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