Preformed donor-specific HLA antibodies in living and deceased donor transplantation: a multicenter study
Background and objectives: The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation. Design, setting, participants, & measurements: The outcome of 4233 consecutive kidney transplants pe...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 5, 2019
|
| In: |
Clinical journal of the American Society of Nephrology
Year: 2019, Jahrgang: 14, Heft: 7, Pages: 1056-1066 |
| ISSN: | 1555-905X |
| DOI: | 10.2215/CJN.13401118 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.2215/CJN.13401118 Verlag: https://cjasn.asnjournals.org/content/14/7/1056 
|
| Verfasserangaben: | Malte Ziemann, Wolfgang Altermann, Katharina Angert, Wolfgang Arns, Anette Bachmann, Tamam Bakchoul, Bernhard Banas, Annette von Borstel, Klemens Budde, Vanessa Ditt, Gunilla Einecke, Ute Eisenberger, Thorsten Feldkamp, Siegfried Görg, Martina Guthoff, Antje Habicht, Michael Hallensleben, Falko M. Heinemann, Nicole Hessler, Christian Hugo, Matthias Kaufmann, Teresa Kauke, Martina Koch, Inke R. König, Christine Kurschat, Claudia Lehmann, Matthias Marget, Anja Mühlfeld, Martin Nitschke, Luiza Pego da Silva, Carmen Quick, Axel Rahmel, Thomas Rath, Petra Reinke, Lutz Renders, Florian Sommer, Bernd Spriewald, Oliver Staeck, Dirk Stippel, Caner Süsal, Bernhard Thiele, Daniel Zecher, Nils Lachmann |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1679234382 | ||
| 003 | DE-627 | ||
| 005 | 20220817004132.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191021s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2215/CJN.13401118 |2 doi | |
| 035 | |a (DE-627)1679234382 | ||
| 035 | |a (DE-599)KXP1679234382 | ||
| 035 | |a (OCoLC)1341248154 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ziemann, Malte |d 1972- |e VerfasserIn |0 (DE-588)121879941 |0 (DE-627)705688186 |0 (DE-576)29293405X |4 aut | |
| 245 | 1 | 0 | |a Preformed donor-specific HLA antibodies in living and deceased donor transplantation |b a multicenter study |c Malte Ziemann, Wolfgang Altermann, Katharina Angert, Wolfgang Arns, Anette Bachmann, Tamam Bakchoul, Bernhard Banas, Annette von Borstel, Klemens Budde, Vanessa Ditt, Gunilla Einecke, Ute Eisenberger, Thorsten Feldkamp, Siegfried Görg, Martina Guthoff, Antje Habicht, Michael Hallensleben, Falko M. Heinemann, Nicole Hessler, Christian Hugo, Matthias Kaufmann, Teresa Kauke, Martina Koch, Inke R. König, Christine Kurschat, Claudia Lehmann, Matthias Marget, Anja Mühlfeld, Martin Nitschke, Luiza Pego da Silva, Carmen Quick, Axel Rahmel, Thomas Rath, Petra Reinke, Lutz Renders, Florian Sommer, Bernd Spriewald, Oliver Staeck, Dirk Stippel, Caner Süsal, Bernhard Thiele, Daniel Zecher, Nils Lachmann |
| 264 | 1 | |c July 5, 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.10.2019 | ||
| 520 | |a Background and objectives: The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation. Design, setting, participants, & measurements: The outcome of 4233 consecutive kidney transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most centers used a stepwise pretransplant antibody screening with bead array tests and differentiation of positive samples by single antigen assays. Using these screening results, DSA against HLA-A, -B, -C, -DRB1 and -DQB1 were determined. Data on clinical outcome and possible covariates were collected retrospectively. Results: Pretransplant DSA were associated with lower overall graft survival, with a hazard ratio of 2.53 for living donation (95% confidence interval [95% CI], 1.49 to 4.29; P<0.001) and 1.59 for deceased donation (95% CI, 1.21 to 2.11; P=0.001). ABO-incompatible transplantation was associated with worse graft survival (hazard ratio, 2.09; 95% CI, 1.33 to 3.27; P=0.001) independent from DSA. There was no difference between DSA against class 1, class 2, or both. Stratification into DSA <3000 medium fluorescence intensity (MFI) and DSA ≥3000 MFI resulted in overlapping survival curves. Therefore, separate analyses were performed for 3-month and long-term graft survival. Although DSA <3000 MFI tended to be associated with both lower 3-month and long-term transplant survival in deceased donation, DSA ≥3000 MFI were only associated with worse long-term transplant survival in deceased donation. In living donation, only strong DSA were associated with reduced graft survival in the first 3 months, but both weak and strong DSA were associated with reduced long-term graft survival. A higher incidence of antibody-mediated rejection within 6 months was only associated with DSA ≥3000 MFI. Conclusions: Preformed DSA were associated with an increased risk for graft loss in kidney transplantation, which was greater in living than in deceased donation. Even weak DSA <3000 MFI were associated with worse graft survival. This association was stronger in living than deceased donation. | ||
| 650 | 4 | |a ABO-incompatible transplantation | |
| 650 | 4 | |a Antibodies | |
| 650 | 4 | |a donor-specific HLA antibodies | |
| 650 | 4 | |a Fluorescence | |
| 650 | 4 | |a graft survival | |
| 650 | 4 | |a HLA-A Antigens | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a preformed HLA antibodies | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Retrospective Studies | |
| 650 | 4 | |a Tissue Donors | |
| 700 | 1 | |a Süsal, Caner |e VerfasserIn |0 (DE-588)102648037X |0 (DE-627)726772763 |0 (DE-576)37182673X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American Society of Nephrology |t Clinical journal of the American Society of Nephrology |d Washington, DC : American Society of Nephrology, 2006 |g 14(2019), 7, Seite 1056-1066 |h Online-Ressource |w (DE-627)50595091X |w (DE-600)2216582-4 |w (DE-576)30683281X |x 1555-905X |7 nnas |
| 773 | 1 | 8 | |g volume:14 |g year:2019 |g number:7 |g pages:1056-1066 |g extent:11 |a Preformed donor-specific HLA antibodies in living and deceased donor transplantation a multicenter study |
| 856 | 4 | 0 | |u https://doi.org/10.2215/CJN.13401118 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://cjasn.asnjournals.org/content/14/7/1056 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191021 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 102648037X |a Süsal, Caner |m 102648037X:Süsal, Caner |d 910000 |d 911600 |e 910000PS102648037X |e 911600PS102648037X |k 0/910000/ |k 1/910000/911600/ |p 40 | ||
| 999 | |a KXP-PPN1679234382 |e 352573543X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"subtitle":"a multicenter study","title":"Preformed donor-specific HLA antibodies in living and deceased donor transplantation","title_sort":"Preformed donor-specific HLA antibodies in living and deceased donor transplantation"}],"person":[{"family":"Ziemann","given":"Malte","display":"Ziemann, Malte","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Caner","family":"Süsal","role":"aut","display":"Süsal, Caner","roleDisplay":"VerfasserIn"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 21.10.2019"],"language":["eng"],"recId":"1679234382","origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"July 5, 2019"}],"id":{"eki":["1679234382"],"doi":["10.2215/CJN.13401118"]},"name":{"displayForm":["Malte Ziemann, Wolfgang Altermann, Katharina Angert, Wolfgang Arns, Anette Bachmann, Tamam Bakchoul, Bernhard Banas, Annette von Borstel, Klemens Budde, Vanessa Ditt, Gunilla Einecke, Ute Eisenberger, Thorsten Feldkamp, Siegfried Görg, Martina Guthoff, Antje Habicht, Michael Hallensleben, Falko M. Heinemann, Nicole Hessler, Christian Hugo, Matthias Kaufmann, Teresa Kauke, Martina Koch, Inke R. König, Christine Kurschat, Claudia Lehmann, Matthias Marget, Anja Mühlfeld, Martin Nitschke, Luiza Pego da Silva, Carmen Quick, Axel Rahmel, Thomas Rath, Petra Reinke, Lutz Renders, Florian Sommer, Bernd Spriewald, Oliver Staeck, Dirk Stippel, Caner Süsal, Bernhard Thiele, Daniel Zecher, Nils Lachmann"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"origin":[{"dateIssuedDisp":"2006-","dateIssuedKey":"2006","publisher":"American Society of Nephrology","publisherPlace":"Washington, DC"}],"id":{"issn":["1555-905X"],"eki":["50595091X"],"zdb":["2216582-4"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Clinical journal of the American Society of Nephrology","title":"Clinical journal of the American Society of Nephrology","subtitle":"CJASN"}],"note":["Gesehen am 04.08.2025"],"disp":"American Society of NephrologyClinical journal of the American Society of Nephrology","type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"50595091X","corporate":[{"display":"American Society of Nephrology","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"pubHistory":["1.2006 -"],"part":{"issue":"7","pages":"1056-1066","year":"2019","extent":"11","text":"14(2019), 7, Seite 1056-1066","volume":"14"},"titleAlt":[{"title":"CJASN"}]}]} | ||
| SRT | |a ZIEMANNMALPREFORMEDD5201 | ||