Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells
Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 April 2019
|
| In: |
International journal of cancer
Year: 2019, Jahrgang: 145, Heft: 8, Pages: 2182-2200 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.32312 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1002/ijc.32312 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32312 
|
| Verfasserangaben: | Daisuke Kyuno, Kun Zhao, Martina Schnölzer, Jan Provaznik, Thilo Hackert and Margot Zöller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1679239120 | ||
| 003 | DE-627 | ||
| 005 | 20220817004210.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191021s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.32312 |2 doi | |
| 035 | |a (DE-627)1679239120 | ||
| 035 | |a (DE-599)KXP1679239120 | ||
| 035 | |a (OCoLC)1341248285 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kyuno, Daisuke |e VerfasserIn |0 (DE-588)118258697X |0 (DE-627)166283098X |4 aut | |
| 245 | 1 | 0 | |a Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells |c Daisuke Kyuno, Kun Zhao, Martina Schnölzer, Jan Provaznik, Thilo Hackert and Margot Zöller |
| 264 | 1 | |c 04 April 2019 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.10.2019 | ||
| 520 | |a Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-enriched membrane domain (GEM)-derived cld7 is recruited into distinct TEX. TEXs were derived from CIC or cld7kd cells of a rat pancreatic and a human colon cancer line. TEX derived from pancreatic cancer cld7kd cells rescued with palmitoylation site-deficient cld7 (cld7mP) allowed selectively evaluating the contribution of GEM-derived TEX, only palmitoylated cld7 being integrated into GEM. Cld7 CIC-TEX promoted tumor cell dissemination and metastatic growth without a major impact on proliferation, apoptosis resistance and epithelial-mesenchymal transition. Instead, migration, invasion and (lymph)angiogenesis were strongly supported, only migration being selectively fostered by GEM-derived cld7 TEX. CIC-TEX coculture of cld7kd cells uncovered significant changes in the cld7kd cell protein and miRNA profiles. However, changes did not correspond to the CIC-TEX profile, CIC-TEX rather initiating integrin, protease and RTK, particularly lymphangiogenic receptor activation. CIC-TEX preferentially rescuing cld7kd-associated defects in signal transduction was backed up by an RTK inhibitor neutralizing the impact of CIC-TEX on tumor progression. In conclusion, cld7 contributes to selective steps of the metastatic cascade. Defects of cld7kd and cld7mP cells in migration, invasion and (lymph)angiogenesis are effaced by CIC-TEX that act by signaling cascade activation. Accordingly, RTK inhibitors are an efficient therapeutic defeating CIC-TEX. | ||
| 650 | 4 | |a claudin7 | |
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a pancreatic cancer | |
| 650 | 4 | |a tumor cell reprogramming | |
| 650 | 4 | |a tumor exosomes | |
| 700 | 1 | |a Zhao, Kun |d 1989- |e VerfasserIn |0 (DE-588)1165062011 |0 (DE-627)1029258414 |0 (DE-576)510224881 |4 aut | |
| 700 | 1 | |a Schnölzer, Martina |e VerfasserIn |0 (DE-588)1158026110 |0 (DE-627)1021753610 |0 (DE-576)503538213 |4 aut | |
| 700 | 1 | |a Hackert, Thilo |d 1971- |e VerfasserIn |0 (DE-588)122158512 |0 (DE-627)70579346X |0 (DE-576)182659208 |4 aut | |
| 700 | 1 | |a Zöller, Margot |d 1943- |e VerfasserIn |0 (DE-588)1071580337 |0 (DE-627)826058647 |0 (DE-576)433167572 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 145(2019), 8, Seite 2182-2200 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells |
| 773 | 1 | 8 | |g volume:145 |g year:2019 |g number:8 |g pages:2182-2200 |g extent:19 |a Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.32312 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32312 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191021 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1071580337 |a Zöller, Margot |m 1071580337:Zöller, Margot |d 910000 |d 910200 |e 910000PZ1071580337 |e 910200PZ1071580337 |k 0/910000/ |k 1/910000/910200/ | ||
| 998 | |g 122158512 |a Hackert, Thilo |m 122158512:Hackert, Thilo |d 910000 |d 910200 |e 910000PH122158512 |e 910200PH122158512 |k 0/910000/ |k 1/910000/910200/ | ||
| 998 | |g 1158026110 |a Schnölzer, Martina |m 1158026110:Schnölzer, Martina |d 140000 |e 140000PS1158026110 |k 0/140000/ | ||
| 998 | |g 1165062011 |a Zhao, Kun |m 1165062011:Zhao, Kun |d 910000 |d 910200 |e 910000PZ1165062011 |e 910200PZ1165062011 |k 0/910000/ |k 1/910000/910200/ | ||
| 998 | |g 118258697X |a Kyuno, Daisuke |m 118258697X:Kyuno, Daisuke |d 910000 |d 910200 |e 910000PK118258697X |e 910200PK118258697X |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1679239120 |e 3525747713 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1679239120"],"doi":["10.1002/ijc.32312"]},"origin":[{"dateIssuedDisp":"04 April 2019","dateIssuedKey":"2019"}],"name":{"displayForm":["Daisuke Kyuno, Kun Zhao, Martina Schnölzer, Jan Provaznik, Thilo Hackert and Margot Zöller"]},"relHost":[{"part":{"volume":"145","text":"145(2019), 8, Seite 2182-2200","extent":"19","year":"2019","pages":"2182-2200","issue":"8"},"titleAlt":[{"title":"Predictive oncology"}],"titleTranslated":[{"translated":"Journal international du cancer"}],"pubHistory":["1.1966 -"],"language":["eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"International Union against Cancer","role":"isb"}],"recId":"269532781","disp":"Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cellsInternational journal of cancer","note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer","title":"International journal of cancer","title_sort":"International journal of cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1097-0215"],"eki":["269532781"],"doi":["10.1002/(ISSN)1097-0215"],"zdb":["1474822-8"]},"origin":[{"dateIssuedKey":"1966","publisher":"Wiley-Liss","dateIssuedDisp":"1966-","publisherPlace":"Bognor Regis"}]}],"physDesc":[{"extent":"19 S."}],"title":[{"title":"Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells","title_sort":"Claudin7-dependent exosome-promoted reprogramming of nonmetastasizing tumor cells"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Kyuno, Daisuke","given":"Daisuke","family":"Kyuno"},{"given":"Kun","family":"Zhao","role":"aut","roleDisplay":"VerfasserIn","display":"Zhao, Kun"},{"family":"Schnölzer","given":"Martina","display":"Schnölzer, Martina","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Hackert","given":"Thilo","roleDisplay":"VerfasserIn","display":"Hackert, Thilo","role":"aut"},{"given":"Margot","family":"Zöller","role":"aut","roleDisplay":"VerfasserIn","display":"Zöller, Margot"}],"recId":"1679239120","language":["eng"],"note":["Gesehen am 21.10.2019"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a KYUNODAISUCLAUDIN7DE0420 | ||