Inter- and intra-observer variability of an anatomical landmark-based, manual segmentation method by MRI for the assessment of skeletal muscle fat content and area in subjects from the general population
Objectives:Changes in skeletal muscle composition, such as fat content and mass, may exert unique metabolic and musculoskeletal risks; however, the reproducibility of their assessment is unknown. We determined the variability of the assessment of skeletal muscle fat content and area by MRI in a popu...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 03, 2018
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| In: |
British journal of radiology
Year: 2018, Jahrgang: 91, Heft: 1089 |
| ISSN: | 1748-880X |
| DOI: | 10.1259/bjr.20180019 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1259/bjr.20180019 Verlag, Volltext: https://www.birpublications.org/doi/10.1259/bjr.20180019 
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| Verfasserangaben: | Lena Sophie Kiefer, Jana Fabian, Roberto Lorbeer, Jürgen Machann, Corinna Storz, Mareen Sarah Kraus, Elke Wintermeyer, Christopher Schlett, Frank Roemer, Konstantin Nikolaou, Annette Peters, and Fabian Bamberg |
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| 245 | 1 | 0 | |a Inter- and intra-observer variability of an anatomical landmark-based, manual segmentation method by MRI for the assessment of skeletal muscle fat content and area in subjects from the general population |c Lena Sophie Kiefer, Jana Fabian, Roberto Lorbeer, Jürgen Machann, Corinna Storz, Mareen Sarah Kraus, Elke Wintermeyer, Christopher Schlett, Frank Roemer, Konstantin Nikolaou, Annette Peters, and Fabian Bamberg |
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| 520 | |a Objectives:Changes in skeletal muscle composition, such as fat content and mass, may exert unique metabolic and musculoskeletal risks; however, the reproducibility of their assessment is unknown. We determined the variability of the assessment of skeletal muscle fat content and area by MRI in a population-based sample.Methods:A random sample from a prospective, community-based cohort study (KORA-FF4) was included. Skeletal muscle fat content was quantified as proton-density fat fraction (PDFF) and area as cross-sectional area (CSA) in multi-echo Dixon sequences (TR 8.90 ms, six echo times, flip angle 4°) by a standardized, anatomical landmark-based, manual skeletal muscle segmentation at level L3 vertebra by two independent observers. Reproducibility was assessed by intraclass correlation coefficients (ICC), scatter and Bland-Altman plots.Results:From 50 subjects included (mean age 56.1 ± 8.8 years, 60.0% males, mean body mass index 28.3 ± 5.2) 2′400 measurements were obtained. Interobserver agreement was excellent for all muscle compartments (PDFF: ICC0.99, CSA: ICC0.98) with only minor absolute and relative differences (-0.2 ± 0.5%, 31 ± 44.7 mm2; -2.6 ± 6.4% and 2.7 ± 3.9%, respectively). Intra-observer reproducibility was similarly excellent (PDFF: ICC1.0, 0.0 ± 0.4%, 0.4%; CSA: ICC1.0, 5.5 ± 25.3 mm2, 0.5%, absolute and relative differences, respectively). All agreement was independent of age, gender, body mass index, body height and visceral adipose tissue (ICC0.96-1.0). Furthermore, PDFF reproducibility was independent of CSA (ICC0.93-0.99). Conclusions: Quantification of skeletal muscle fat content and area by MRI using an anatomical landmark-based, manual skeletal muscle segmentation is highly reproducible.Advances in knowledge:An anatomical landmark-based, manual skeletal muscle segmentation provides high reproducibility of skeletal muscle fat content and area and may therefore serve as a robust proxy for myosteatosis and sarcopenia in large cohort studies. | ||
| 700 | 1 | |a Fabian, Jana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lorbeer, Roberto |e VerfasserIn |4 aut | |
| 700 | 1 | |a Machann, Jürgen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Storz, Corinna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kraus, Mareen Sarah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wintermeyer, Elke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlett, Christopher L. |d 1983- |e VerfasserIn |0 (DE-588)1022729977 |0 (DE-627)717033945 |0 (DE-576)36586398X |4 aut | |
| 700 | 1 | |a Roemer, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nikolaou, Konstantin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peters, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bamberg, Fabian |e VerfasserIn |4 aut | |
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