Cellular functions and mechanisms of action of small heat shock proteins
Small heat shock proteins (sHsps) constitute a diverse chaperone family that shares the α-crystallin domain, which is flanked by variable, disordered N- and C-terminal extensions. sHsps act as the first line of cellular defense against protein unfolding stress. They form dynamic, large oligomers tha...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
Annual review of microbiology
Year: 2019, Jahrgang: 73, Heft: 1, Pages: 89-110 |
| ISSN: | 1545-3251 |
| DOI: | 10.1146/annurev-micro-020518-115515 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1146/annurev-micro-020518-115515 Verlag: https://www.annualreviews.org/doi/10.1146/annurev-micro-020518-115515 
|
| Verfasserangaben: | Axel Mogk, Carmen Ruger-Herreros, and Bernd Bukau |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1679284983 | ||
| 003 | DE-627 | ||
| 005 | 20220817004613.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191022s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1146/annurev-micro-020518-115515 |2 doi | |
| 035 | |a (DE-627)1679284983 | ||
| 035 | |a (DE-599)KXP1679284983 | ||
| 035 | |a (OCoLC)1341248450 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Mogk, Axel |e VerfasserIn |0 (DE-588)102799914X |0 (DE-627)73031166X |0 (DE-576)180449338 |4 aut | |
| 245 | 1 | 0 | |a Cellular functions and mechanisms of action of small heat shock proteins |c Axel Mogk, Carmen Ruger-Herreros, and Bernd Bukau |
| 264 | 1 | |c 2019 | |
| 300 | |a 22 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.10.2019 | ||
| 520 | |a Small heat shock proteins (sHsps) constitute a diverse chaperone family that shares the α-crystallin domain, which is flanked by variable, disordered N- and C-terminal extensions. sHsps act as the first line of cellular defense against protein unfolding stress. They form dynamic, large oligomers that represent inactive storage forms. Stress conditions cause a rapid increase in cellular sHsp levels and trigger conformational rearrangements, resulting in exposure of substrate-binding sites and sHsp activation. sHsps bind to early-unfolding intermediates of misfolding proteins in an ATP-independent manner and sequester them in sHsp/substrate complexes. Sequestration protects substrates from further uncontrolled aggregation and facilitates their refolding by ATP-dependent Hsp70-Hsp100 disaggregases. Some sHsps with particularly strong sequestrase activity, such as yeast Hsp42, are critical factors for forming large, microscopically visible deposition sites of misfolded proteins in vivo. These sites are organizing centers for triaging substrates to distinct quality control pathways, preferentially Hsp70-dependent refolding and selective autophagy. | ||
| 700 | 1 | |a Ruger-Herreros, Carmen |e VerfasserIn |0 (DE-588)1197625933 |0 (DE-627)1679285890 |4 aut | |
| 700 | 1 | |a Bukau, Bernd |d 1954- |e VerfasserIn |0 (DE-588)143209019 |0 (DE-627)643892575 |0 (DE-576)335649270 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annual review of microbiology |d Palo Alto, Calif. : Annual Reviews Inc., 1947 |g 73(2019), 1, Seite 89-110 |h Online-Ressource |w (DE-627)267833830 |w (DE-600)1470471-7 |w (DE-576)077169743 |x 1545-3251 |7 nnas |a Cellular functions and mechanisms of action of small heat shock proteins |
| 773 | 1 | 8 | |g volume:73 |g year:2019 |g number:1 |g pages:89-110 |g extent:22 |a Cellular functions and mechanisms of action of small heat shock proteins |
| 856 | 4 | 0 | |u https://doi.org/10.1146/annurev-micro-020518-115515 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.annualreviews.org/doi/10.1146/annurev-micro-020518-115515 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20191022 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 143209019 |a Bukau, Bernd |m 143209019:Bukau, Bernd |d 700000 |d 706000 |e 700000PB143209019 |e 706000PB143209019 |k 0/700000/ |k 1/700000/706000/ |p 3 |y j | ||
| 998 | |g 1197625933 |a Ruger-Herreros, Carmen |m 1197625933:Ruger-Herreros, Carmen |d 700000 |d 706000 |e 700000PR1197625933 |e 706000PR1197625933 |k 0/700000/ |k 1/700000/706000/ |p 2 | ||
| 998 | |g 102799914X |a Mogk, Axel |m 102799914X:Mogk, Axel |d 700000 |d 706000 |e 700000PM102799914X |e 706000PM102799914X |k 0/700000/ |k 1/700000/706000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1679284983 |e 3526024545 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","family":"Mogk","display":"Mogk, Axel","given":"Axel"},{"given":"Carmen","role":"aut","family":"Ruger-Herreros","display":"Ruger-Herreros, Carmen"},{"role":"aut","family":"Bukau","display":"Bukau, Bernd","given":"Bernd"}],"note":["Gesehen am 22.10.2019"],"language":["eng"],"name":{"displayForm":["Axel Mogk, Carmen Ruger-Herreros, and Bernd Bukau"]},"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"id":{"doi":["10.1146/annurev-micro-020518-115515"],"eki":["1679284983"]},"recId":"1679284983","type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"22 S."}],"title":[{"title":"Cellular functions and mechanisms of action of small heat shock proteins","title_sort":"Cellular functions and mechanisms of action of small heat shock proteins"}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"267833830","id":{"zdb":["1470471-7"],"eki":["267833830"],"issn":["1545-3251"]},"origin":[{"publisher":"Annual Reviews Inc.","dateIssuedDisp":"1947-","dateIssuedKey":"1947","publisherPlace":"Palo Alto, Calif."}],"disp":"Cellular functions and mechanisms of action of small heat shock proteinsAnnual review of microbiology","language":["eng"],"titleAlt":[{"title":"Annual reviews / Biomedical sciences / Annual review of microbiology"}],"pubHistory":["1.1947 -"],"note":["Gesehen am 19.01.05"],"part":{"year":"2019","pages":"89-110","issue":"1","extent":"22","text":"73(2019), 1, Seite 89-110","volume":"73"},"title":[{"title_sort":"Annual review of microbiology","title":"Annual review of microbiology"}],"physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a MOGKAXELRUCELLULARFU2019 | ||