Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo
Reactive oxygen species (ROS) are involved in the pathophysiology of several health disorders, among others inflammation. Polyphenols may modulate ROS related disorders. In this work, thirty-two phenolic compounds were tentatively identified in a leaf extract from Eugenia supra-axillaris Spring. ex...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 July 2019
|
| In: |
Scientific reports
Year: 2019, Volume: 9 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-46946-7 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-019-46946-7 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-019-46946-7 
|
| Author Notes: | Nesrine M. Hegazi, Mansour Sobeh, Samar Rezq, Mohamed A. El-Raey, Malak Dmirieh, Assem M. El-Shazly, Mona F. Mahmoud & Michael Wink |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1679351354 | ||
| 003 | DE-627 | ||
| 005 | 20230426155237.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191022s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-019-46946-7 |2 doi | |
| 035 | |a (DE-627)1679351354 | ||
| 035 | |a (DE-599)KXP1679351354 | ||
| 035 | |a (OCoLC)1264108340 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Hegazi, Nesrine M. |e VerfasserIn |0 (DE-588)1197652795 |0 (DE-627)1679349597 |4 aut | |
| 245 | 1 | 0 | |a Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo |c Nesrine M. Hegazi, Mansour Sobeh, Samar Rezq, Mohamed A. El-Raey, Malak Dmirieh, Assem M. El-Shazly, Mona F. Mahmoud & Michael Wink |
| 264 | 1 | |c 31 July 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.10.2019 | ||
| 520 | |a Reactive oxygen species (ROS) are involved in the pathophysiology of several health disorders, among others inflammation. Polyphenols may modulate ROS related disorders. In this work, thirty-two phenolic compounds were tentatively identified in a leaf extract from Eugenia supra-axillaris Spring. ex Mart. using HPLC-MS/MS, five of which were also individually isolated and identified. The extract displayed a substantial in vitro antioxidant potential and was capable of decreasing ROS production and hsp-16.2 expression under oxidative stress conditions in vivo in the Caenorhabditis elegans model. Also, the extract showed higher inhibitory selectivity towards COX-2 than COX-1 in vitro with higher selectivity towards COX-2 than that of diclofenac. The extract also exhibited anti-inflammatory properties: It attenuated the edema thickness in a dose dependent fashion in carrageenan-induced hind-paw odema in rats. In addition, the extract reduced the carrageenan-induced leukocyte migration into the peritoneal cavity at the highest dose. Furthermore, the extract showed antipyretic and analgesic activities in a mouse model. Eugenia supra-axillaris appears to be a promising candidate in treating inflammation, pain and related oxidative stress diseases. | ||
| 700 | 1 | |a Sobeh, Mansour |e VerfasserIn |0 (DE-588)1099730058 |0 (DE-627)859130444 |0 (DE-576)469346434 |4 aut | |
| 700 | 1 | |a Rezq, Samar |e VerfasserIn |4 aut | |
| 700 | 1 | |a El-Raey, Mohamed A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dmirieh, Malak |d 1985- |e VerfasserIn |0 (DE-588)1153030705 |0 (DE-627)1014406587 |0 (DE-576)499840305 |4 aut | |
| 700 | 1 | |a El-Shazly, Assem M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mahmoud, Mona F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wink, Michael |d 1951- |e VerfasserIn |0 (DE-588)124618146 |0 (DE-627)363448519 |0 (DE-576)164659390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 9(2019) Artikel-Nummer 11122, 12 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo |
| 773 | 1 | 8 | |g volume:9 |g year:2019 |a Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41598-019-46946-7 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-019-46946-7 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191022 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124618146 |a Wink, Michael |m 124618146:Wink, Michael |d 160000 |d 160100 |e 160000PW124618146 |e 160100PW124618146 |k 0/160000/ |k 1/160000/160100/ |p 8 |y j | ||
| 998 | |g 1153030705 |a Dmirieh, Malak |m 1153030705:Dmirieh, Malak |d 160000 |d 160100 |e 160000PD1153030705 |e 160100PD1153030705 |k 0/160000/ |k 1/160000/160100/ |p 5 | ||
| 998 | |g 1099730058 |a Sobeh, Mansour |m 1099730058:Sobeh, Mansour |d 160000 |d 160100 |e 160000PS1099730058 |e 160100PS1099730058 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 999 | |a KXP-PPN1679351354 |e 3526183619 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1679351354","note":["Gesehen am 22.10.2019"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"title":[{"title_sort":"Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo","title":"Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo"}],"id":{"eki":["1679351354"],"doi":["10.1038/s41598-019-46946-7"]},"person":[{"given":"Nesrine M.","role":"aut","family":"Hegazi","display":"Hegazi, Nesrine M."},{"given":"Mansour","role":"aut","family":"Sobeh","display":"Sobeh, Mansour"},{"given":"Samar","role":"aut","family":"Rezq","display":"Rezq, Samar"},{"family":"El-Raey","given":"Mohamed A.","role":"aut","display":"El-Raey, Mohamed A."},{"role":"aut","given":"Malak","family":"Dmirieh","display":"Dmirieh, Malak"},{"role":"aut","given":"Assem M.","family":"El-Shazly","display":"El-Shazly, Assem M."},{"display":"Mahmoud, Mona F.","given":"Mona F.","role":"aut","family":"Mahmoud"},{"given":"Michael","role":"aut","family":"Wink","display":"Wink, Michael"}],"relHost":[{"disp":"Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivoScientific reports","physDesc":[{"extent":"Online-Ressource"}],"recId":"663366712","note":["Gesehen am 12.07.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"title":[{"title":"Scientific reports","title_sort":"Scientific reports"}],"part":{"text":"9(2019) Artikel-Nummer 11122, 12 Seiten","volume":"9","year":"2019"},"id":{"zdb":["2615211-3"],"eki":["663366712"],"issn":["2045-2322"]},"pubHistory":["1, article number 1 (2011)-"],"origin":[{"publisher":"Springer Nature ; Nature Publishing Group","dateIssuedDisp":"2011-","dateIssuedKey":"2011","publisherPlace":"[London] ; London"}]}],"name":{"displayForm":["Nesrine M. Hegazi, Mansour Sobeh, Samar Rezq, Mohamed A. El-Raey, Malak Dmirieh, Assem M. El-Shazly, Mona F. Mahmoud & Michael Wink"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"31 July 2019"}]} | ||
| SRT | |a HEGAZINESRCHARACTERI3120 | ||