Cover Image

The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation

Background. Chronic pancreatitis is one of the main risk factors for pancreatic cancer. In acute and chronic pancreatitis, oxidative stress is thought to play a key role. In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at n...

Full description

Saved in:
Bibliographic Details
Main Authors: Weniger, Maximilian (Author) , Bazhin, Alexandr V. (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Oxidative medicine and cellular longevity

ISSN:1942-0994
DOI:undefined
Online Access:Verlag, Volltext: https://doi.org/undefined
Verlag: https://www.hindawi.com/journals/omcl/2016/4650489/
Get full text
Author Notes:Maximilian Weniger, Leonard Reinelt, Jens Neumann, Lesca Holdt, Matthias Ilmer, Bernhard Renz, Werner Hartwig, Jens Werner, Alexandr V. Bazhin, and Jan G. D’Haese

MARC

LEADER 00000caa a2200000 c 4500
001 167976604X
003 DE-627
005 20230427134456.0
007 cr uuu---uuuuu
008 191024s2016 xx |||||o 00| ||eng c
035 |a (DE-627)167976604X 
035 |a (DE-599)KXP167976604X 
035 |a (OCoLC)1341249298 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Weniger, Maximilian  |d 1988-  |e VerfasserIn  |0 (DE-588)1170925650  |0 (DE-627)1040241859  |0 (DE-576)512718830  |4 aut 
245 1 4 |a The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation  |c Maximilian Weniger, Leonard Reinelt, Jens Neumann, Lesca Holdt, Matthias Ilmer, Bernhard Renz, Werner Hartwig, Jens Werner, Alexandr V. Bazhin, and Jan G. D’Haese 
264 1 |c 2016 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 24.10.2019 
520 |a Background. Chronic pancreatitis is one of the main risk factors for pancreatic cancer. In acute and chronic pancreatitis, oxidative stress is thought to play a key role. In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at nanomolar concentrations. Therefore, we aimed to characterize the influence of SkQ1 on tissue injury and pain in acute and chronic pancreatitis. Methods. Both acute and chronic pancreatitis were induced in C57BL/6 mice by intraperitoneal cerulein injections and treatment with SkQ1 was carried out by peroral applications. Hyperalgesia was assessed by behavioral observation and measurement of abdominal mechanical sensitivity. Blood serum and pancreatic tissue were harvested for analysis of lipase and histology. Results. SkQ1 did not influence pain, serological, or histological parameters of tissue injury in acute pancreatitis. In chronic pancreatitis, a highly significant reduction of pain-related behavior () was evident, but histological grading revealed increased tissue injury in SkQ1-treated animals (). Conclusion. After SkQ1 treatment, tissue injury is not ameliorated in acute pancreatitis and increased in chronic pancreatitis. However, we show an analgesic effect in chronic pancreatitis. Further studies will need to elucidate the risks and benefits of mitochondria-targeted antioxidants as an analgesic. 
700 1 |a Bazhin, Alexandr V.  |e VerfasserIn  |0 (DE-588)1025289552  |0 (DE-627)721987710  |0 (DE-576)370168046  |4 aut 
773 0 8 |i Enthalten in  |t Oxidative medicine and cellular longevity  |d [Hoboken, NJ : Wiley], 2008  |g (2016) Artikel-Nummer 4650489, 10 Seiten  |h Online-Ressource  |w (DE-627)582019079  |w (DE-600)2455981-7  |w (DE-576)347281796  |x 1942-0994  |7 nnas  |a The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation 
773 1 8 |g year:2016  |g extent:10  |a The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation 
856 4 0 |u https://doi.org/undefined  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://www.hindawi.com/journals/omcl/2016/4650489/  |x Verlag 
951 |a AR 
992 |a 20191024 
993 |a Article 
994 |a 2016 
998 |g 1025289552  |a Bazhin, Alexandr V.  |m 1025289552:Bazhin, Alexandr V.  |d 60000  |d 61900  |e 60000PB1025289552  |e 61900PB1025289552  |k 0/60000/  |k 1/60000/61900/ 
999 |a KXP-PPN167976604X  |e 3526983038 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["167976604X"]},"origin":[{"dateIssuedDisp":"2016","dateIssuedKey":"2016"}],"name":{"displayForm":["Maximilian Weniger, Leonard Reinelt, Jens Neumann, Lesca Holdt, Matthias Ilmer, Bernhard Renz, Werner Hartwig, Jens Werner, Alexandr V. Bazhin, and Jan G. D’Haese"]},"relHost":[{"title":[{"title":"Oxidative medicine and cellular longevity","title_sort":"Oxidative medicine and cellular longevity"}],"origin":[{"publisherPlace":"[Hoboken, NJ ; Austin, Tex.","dateIssuedKey":"2024","publisher":"Wiley] ; Landes Bioscience","dateIssuedDisp":"2024-"}],"id":{"issn":["1942-0994"],"eki":["582019079"],"zdb":["2455981-7"]},"disp":"The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammationOxidative medicine and cellular longevity","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"582019079","language":["eng"],"pubHistory":["1.2008-"],"part":{"text":"(2016) Artikel-Nummer 4650489, 10 Seiten","extent":"10","year":"2016"}}],"physDesc":[{"extent":"10 S."}],"title":[{"title":"The analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation","title_sort":"analgesic effect of the mitochondria-targeted antioxidant SkQ1 in pancreatic inflammation"}],"person":[{"given":"Maximilian","family":"Weniger","role":"aut","roleDisplay":"VerfasserIn","display":"Weniger, Maximilian"},{"display":"Bazhin, Alexandr V.","roleDisplay":"VerfasserIn","role":"aut","family":"Bazhin","given":"Alexandr V."}],"language":["eng"],"recId":"167976604X","note":["Gesehen am 24.10.2019"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} 
SRT |a WENIGERMAXANALGESICE2016 

Similar Items