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An ultrasensitive UPLC-MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs

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Aim: An ultrasensitive UPLC-MS/MS assay for liraglutide was developed and validated according to US FDA and EMA guidelines and applied to the quantification of plasma concentrations after intravenous, nasal and oral administration of liraglutide to beagle dogs. Results: Liraglutide isolation was per...

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Main Authors: Sauter, Max (Author) , Uhl, Philipp (Author) , Majewsky, Marius (Author) , Fresnais, Margaux (Author) , Haefeli, Walter E. (Author) , Burhenne, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 16 May 2019
In: Bioanalysis
Year: 2019, Volume: 11, Issue: 9, Pages: 887-898
ISSN:1757-6199
DOI:10.4155/bio-2018-0322
Online Access:Verlag, Volltext: https://doi.org/10.4155/bio-2018-0322
Verlag, Volltext: https://www.future-science.com/doi/10.4155/bio-2018-0322
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Author Notes:Max Sauter, Philipp Uhl, Marius Majewsky, Margaux Fresnais, Walter E Haefeli and Jürgen Burhenne
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An ultrasensitive UPLC–MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs by Sauter, Max (Author) , Uhl, Philipp (Author) , Majewsky, Marius (Author) , Fresnais, Margaux (Author) , Haefeli, Walter E. (Author) , Burhenne, Jürgen (Author) ,

Future Science 2019 Universitätsbibliothek Heidelberg 2019

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