An ultrasensitive UPLC-MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs
Aim: An ultrasensitive UPLC-MS/MS assay for liraglutide was developed and validated according to US FDA and EMA guidelines and applied to the quantification of plasma concentrations after intravenous, nasal and oral administration of liraglutide to beagle dogs. Results: Liraglutide isolation was per...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 May 2019
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| In: |
Bioanalysis
Year: 2019, Jahrgang: 11, Heft: 9, Pages: 887-898 |
| ISSN: | 1757-6199 |
| DOI: | 10.4155/bio-2018-0322 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.4155/bio-2018-0322 Verlag, Volltext: https://www.future-science.com/doi/10.4155/bio-2018-0322 
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| Verfasserangaben: | Max Sauter, Philipp Uhl, Marius Majewsky, Margaux Fresnais, Walter E Haefeli and Jürgen Burhenne |
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An ultrasensitive UPLC–MS/MS assay for the quantification of the therapeutic peptide liraglutide in plasma to assess the oral and nasal bioavailability in beagle dogs
Future Science 2019 Universitätsbibliothek Heidelberg 2019
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