Hepatitis B virus infection of a mouse hepatic cell line reconstituted with human sodium taurocholate cotransporting polypeptide
Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) whic...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 February 2016
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| In: |
Journal of virology
Year: 2016, Volume: 90, Issue: 9, Pages: 4827-4831 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.02832-15 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1128/JVI.02832-15 Verlag, Volltext: https://jvi.asm.org/content/90/9/4827 
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| Author Notes: | Florian A. Lempp, Bingqian Qu, Yong-Xiang Wang, Stephan Urban |
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| 520 | |a Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants. | ||
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