Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor
The Bruton’s tyrosine kinase (BTK) is an essential in the B-cell receptor (BCR) signaling pathway which was identified as crucial in the pathogenesis of B-cell malignancies. Ibrutinib, a first-in-class BTK inhibitor, has been approved for the treatment of distinct B-cell malignancies. To overcome of...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
02 August 2018
|
| In: |
Small molecules in hematology
Year: 2018, Pages: 285-294 |
| DOI: | 10.1007/978-3-319-91439-8_14 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/978-3-319-91439-8_14
|
| Verfasserangaben: | Katharina Kriegsmann, Mark Kriegsmann, Mathias Witzens-Harig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1680563386 | ||
| 003 | DE-627 | ||
| 005 | 20220817012456.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 191029s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/978-3-319-91439-8_14 |2 doi | |
| 035 | |a (DE-627)1680563386 | ||
| 035 | |a (DE-599)KXP1680563386 | ||
| 035 | |a (OCoLC)1341249336 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriegsmann, Katharina |d 1986- |e VerfasserIn |0 (DE-588)1049422449 |0 (DE-627)781924006 |0 (DE-576)40339774X |4 aut | |
| 245 | 1 | 0 | |a Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor |c Katharina Kriegsmann, Mark Kriegsmann, Mathias Witzens-Harig |
| 264 | 1 | |c 02 August 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.10.2019 | ||
| 520 | |a The Bruton’s tyrosine kinase (BTK) is an essential in the B-cell receptor (BCR) signaling pathway which was identified as crucial in the pathogenesis of B-cell malignancies. Ibrutinib, a first-in-class BTK inhibitor, has been approved for the treatment of distinct B-cell malignancies. To overcome off-target side effects of and emerging resistances to ibrutinib, more selective second-generation BTK inhibitors were developed. Acalabrutinib is a novel second-generation BTK inhibitor and has shown promising safety and efficacy profiles in phase 1/2 clinical trials in patients with relapsed CLL and pretreated MCL. Recently, acalabrutinib was approved by the FDA for treatment of adult patients with MCL who received at least one prior therapy. However, clinical trials on a direct comparison between ibrutinib and acalabrutinib and on combination treatment options with other agents as CD20 antibodies are warranted. | ||
| 650 | 4 | |a Acalabrutinib | |
| 650 | 4 | |a Bruton’s tyrosine kinase | |
| 650 | 4 | |a Hematologic malignancies | |
| 700 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 700 | 1 | |a Witzens-Harig, Mathias |e VerfasserIn |0 (DE-588)1050736516 |0 (DE-627)784812322 |0 (DE-576)404988970 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Small molecules in hematology |b Third edition |d Cham, Switzerland : Springer, 2018 |g (2018), Seite 285-294 |h 1 Online-Ressource (VIII, 294 Seiten) |w (DE-627)1030110891 |w (DE-576)510624774 |z 9783319914398 |7 nnam |a Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor |
| 773 | 1 | 8 | |g year:2018 |g pages:285-294 |g extent:10 |a Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-319-91439-8_14 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20191029 | ||
| 993 | |a BookComponentPart | ||
| 994 | |a 2018 | ||
| 998 | |g 1050736516 |a Witzens-Harig, Mathias |m 1050736516:Witzens-Harig, Mathias |d 910000 |d 910100 |e 910000PW1050736516 |e 910100PW1050736516 |k 0/910000/ |k 1/910000/910100/ |p 3 |y j | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 912000 |e 910000PK103740324X |e 912000PK103740324X |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 1049422449 |a Kriegsmann, Katharina |m 1049422449:Kriegsmann, Katharina |d 910000 |d 910100 |e 910000PK1049422449 |e 910100PK1049422449 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1680563386 |e 3530860891 | ||
| BIB | |a Y | ||
| JSO | |a {"relHost":[{"origin":[{"editionNo":3,"dateIssuedKey":"2018","publisher":"Springer","edition":"Third edition","publisherPlace":"Cham, Switzerland","dateIssuedDisp":"[2018]"}],"type":{"bibl":"edited-book","media":"Online-Ressource"},"title":[{"title_sort":"Small molecules in hematology","title":"Small molecules in hematology"}],"part":{"text":"(2018), Seite 285-294","pages":"285-294","year":"2018","extent":"10"},"relMultPart":[{"dispAlt":"Recent results in cancer research","id":{"zdb":["2393522-4"],"eki":["548128227"],"issn":["2197-6767"]},"pubHistory":["Nachgewiesen 165.2006 -"],"part":{"number_sort":["212"],"number":["volume 212"]},"origin":[{"dateIssuedDisp":"2006-","publisherPlace":"Berlin ; Heidelberg","dateIssuedKey":"2006","publisher":"Springer"}],"type":{"media":"Online-Ressource","bibl":"serial"},"title":[{"title_sort":"Recent results in cancer research","title":"Recent results in cancer research"}],"disp":"Recent results in cancer research","recId":"548128227","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"note":["Gesehen am 25.10.07"]}],"disp":"Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitorSmall molecules in hematology","id":{"eki":["1030110891"],"isbn":["9783319914398"],"doi":["10.1007/978-3-319-91439-8"]},"language":["eng"],"person":[{"role":"edt","given":"Uwe Marc","family":"Martens","display":"Martens, Uwe Marc"}],"name":{"displayForm":["Uwe M. Martens, editor"]},"physDesc":[{"extent":"1 Online-Ressource (VIII, 294 Seiten)","noteIll":"Illustrationen, Diagramme"}],"recId":"1030110891"}],"id":{"doi":["10.1007/978-3-319-91439-8_14"],"eki":["1680563386"]},"recId":"1680563386","name":{"displayForm":["Katharina Kriegsmann, Mark Kriegsmann, Mathias Witzens-Harig"]},"physDesc":[{"extent":"10 S."}],"language":["eng"],"note":["Gesehen am 29.10.2019"],"origin":[{"dateIssuedDisp":"02 August 2018","dateIssuedKey":"2018"}],"type":{"media":"Online-Ressource","bibl":"chapter"},"title":[{"title":"Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor","title_sort":"Acalabrutinib, a second-generation Bruton’s tyrosine kinase inhibitor"}],"person":[{"family":"Kriegsmann","display":"Kriegsmann, Katharina","given":"Katharina","role":"aut"},{"family":"Kriegsmann","display":"Kriegsmann, Mark","given":"Mark","role":"aut"},{"display":"Witzens-Harig, Mathias","family":"Witzens-Harig","role":"aut","given":"Mathias"}]} | ||
| SRT | |a KRIEGSMANNACALABRUTI0220 | ||